Method of inhibiting plant virus pathogen infections by crispr/cas9-mediated interference

dc.contributor.assigneeKing Abdullah University Of Science And Technology
dc.contributor.authorMahfouz, Magdy M.
dc.contributor.authorAli, Zahir
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.date.accessioned2017-01-19T07:02:57Z
dc.date.available2017-01-19T07:02:57Z
dc.date.issued2016-11-24
dc.date.submitted2015-05-18
dc.description.abstractA genetically modified tobacco plant or tomato plant resistant to at least one pathogenic geminiviridae virus species is provided. The plant comprises a heterologous CRISPR/Cas9 system and at least one heterologous nucleotide sequence that is capable of hybridizing to a nucleotide sequence of the pathogenic virus and that directs inactivation of the pathogenic virus species or plurality of viral species by the CRISPR/Cas9 system. The heterologous nucleotide sequence can be complementary to, but not limited to an Intergenic Region (IR) of the Tomato Yellow Leaf Curl Virus (TYLCV), Further provided are methods of generating a genetically modified plant that is resistant to a virus pathogen by a heterologous CRISPR/Cas9 system and expression of a gRNA specifically targeting the virus.
dc.description.countryWorld Intellectual Property Organization (WIPO)
dc.description.statusPublished Application
dc.identifier.applicationnumberWO 2016185411 A1
dc.identifier.urihttp://hdl.handle.net/10754/622697
dc.relation.urlhttp://www.google.com/patents/WO2016185411A1
dc.relation.urlhttp://worldwide.espacenet.com/publicationDetails/biblio?CC=WO&NR=2016185411A1&KC=A1&FT=D
dc.titleMethod of inhibiting plant virus pathogen infections by crispr/cas9-mediated interference
dc.typePatent
refterms.dateFOA2018-06-13T17:21:14Z
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