Hydride Transfer Enables the Nickel-Catalyzed ipso-Borylation and Silylation of Aldehydes

Abstract
Nickel-catalyzed ipso-borylations and silylations of aldehydes are described for the first time. The new functional-group interconversion protocol is characterized by its scalability, functional-group tolerance and wide substrate scope, including examples of late-stage functionalization of complex molecules. The key for the successful reaction outcome is the use of a ketone as a hydride acceptor that intercepts the nickel hydride to undergo a reductive pathway, thus allowing formation of the desired C−B and C−Si bonds.

Citation
Srimontree, W., Guo, L., & Rueping, M. (2019). Hydride Transfer Enables the Nickel-Catalyzed ipso -Borylation and Silylation of Aldehydes. Chemistry – A European Journal. doi:10.1002/chem.201904842

Acknowledgements
This research was supported by King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research under award number URF/1/3030-01.

Publisher
Wiley

Journal
Chemistry – A European Journal

DOI
10.1002/chem.201904842

Additional Links
https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201904842https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/chem.201904842

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