Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles

dc.contributor.authorWang, Xiang
dc.contributor.authorLi, Shunbo
dc.contributor.authorWang, Limu
dc.contributor.authorYi, Xin
dc.contributor.authorHui, Yu Sanna
dc.contributor.authorQin, Jianhua
dc.contributor.authorWen, Weijia
dc.contributor.departmentKAUST-HKUST Joint Micro/Nanofluidic Laboratory
dc.contributor.institutionNanoscience and Nanotechnology Program, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
dc.contributor.institutionDepartment of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
dc.contributor.institutionDalian Institute of Chemical Physics, Chinese Academy of Science, 457 Zhongshan Road, Dalian, China
dc.date.accessioned2015-04-16T14:03:08Z
dc.date.available2015-04-16T14:03:08Z
dc.date.issued2013-09-25
dc.date.published-online2013-09-25
dc.date.published-print2013
dc.description.abstractWe report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.
dc.eprint.versionPublisher's Version/PDF
dc.identifier.citationMicrofluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles 2013, 2013:1 Journal of Nanomaterials
dc.identifier.doi10.1155/2013/864584
dc.identifier.issn1687-4110
dc.identifier.issn1687-4129
dc.identifier.journalJournal of Nanomaterials
dc.identifier.urihttp://hdl.handle.net/10754/550220
dc.publisherHindawi Limited
dc.relation.urlhttp://www.hindawi.com/journals/jnm/2013/864584/
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproductio n in any medium, provided the original work is properly cited.
dc.titleMicrofluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles
dc.typeArticle
display.details.left<span><h5>Type</h5>Article<br><br><h5>Authors</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Wang, Xiang,equals">Wang, Xiang</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Li, Shunbo,equals">Li, Shunbo</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Wang, Limu,equals">Wang, Limu</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Yi, Xin,equals">Yi, Xin</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Hui, Yu Sanna,equals">Hui, Yu Sanna</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Qin, Jianhua,equals">Qin, Jianhua</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Wen, Weijia,equals">Wen, Weijia</a><br><br><h5>KAUST Department</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=KAUST-HKUST Joint Micro/Nanofluidic Laboratory,equals">KAUST-HKUST Joint Micro/Nanofluidic Laboratory</a><br><br><h5>Online Publication Date</h5>2013-09-25<br><br><h5>Print Publication Date</h5>2013<br><br><h5>Date</h5>2013-09-25</span>
display.details.right<span><h5>Abstract</h5>We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform’s feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.<br><br><h5>Citation</h5>Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles 2013, 2013:1 Journal of Nanomaterials<br><br><h5>Publisher</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.publisher=Hindawi Limited,equals">Hindawi Limited</a><br><br><h5>Journal</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.journal=Journal of Nanomaterials,equals">Journal of Nanomaterials</a><br><br><h5>DOI</h5><a href="https://doi.org/10.1155/2013/864584">10.1155/2013/864584</a><br><br><h5>Additional Links</h5>http://www.hindawi.com/journals/jnm/2013/864584/</span>
kaust.personLi, Shunbo
kaust.personWen, Weijia
orcid.authorWang, Xiang
orcid.authorLi, Shunbo
orcid.authorWang, Limu
orcid.authorYi, Xin
orcid.authorHui, Yu Sanna
orcid.authorQin, Jianhua
orcid.authorWen, Weijia
refterms.dateFOA2018-06-13T16:52:44Z
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