Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients

dc.contributor.authorConti, Antonio
dc.contributor.authorRiva, Nilo
dc.contributor.authorPesca, Mariasabina Sabina
dc.contributor.authorIannaccone, Sandro
dc.contributor.authorCannistraci, Carlo
dc.contributor.authorCorbo, Massimo
dc.contributor.authorPrevitali, Stefano Carlo
dc.contributor.authorQuattrini, Angelo
dc.contributor.authorAlessio, Massimo
dc.contributor.departmentApplied Mathematics and Computational Science Program
dc.contributor.departmentIntegrative Systems Biology Lab
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.institutionProteome Biochemistry, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
dc.contributor.institutionDepartment of Neurology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
dc.contributor.institutionINSPE-Institute of Experimental Neurology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
dc.contributor.institutionClinical Neurosciences, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
dc.contributor.institutionNeuromuscular Repair, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
dc.contributor.institutionExperimental Neuropathology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
dc.contributor.institutionDepartment of Neurorehabilitation Sciences, Casa Cura Policlinico, Milan, Italy
dc.contributor.institutionFarmaceutical Sciences, Salerno University, Fisciano, SA, Italy
dc.date.accessioned2015-08-03T11:45:03Z
dc.date.available2015-08-03T11:45:03Z
dc.date.issued2014-01
dc.description.abstractAmyotrophic lateral sclerosis (ALS) is a severe and fatal neurodegenerative disease of still unknown pathogenesis. Recent findings suggest that the skeletal muscle may play an active pathogenetic role. To investigate ALS's pathogenesis and to seek diagnostic markers, we analyzed skeletal muscle biopsies with the differential expression proteomic approach. We studied skeletal muscle biopsies from healthy controls (CN), sporadic ALS (sALS), motor neuropathies (MN) and myopathies (M). Pre-eminently among several differentially expressed proteins, Myosin binding protein H (MyBP-H) expression in ALS samples was anomalously high. MyBP-H is a component of the thick filaments of the skeletal muscle and has strong affinity for myosin, but its function is still unclear. High MyBP-H expression level was associated with abnormal expression of Rho kinase 2 (ROCK2), LIM domain kinase 1 (LIMK1) and cofilin2, that might affect the actin-myosin interaction. We propose that MyBP-H expression level serves, as a putative biomarker in the skeletal muscle, to discriminate ALS from motor neuropathies, and that it signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of ALS. © 2013 Elsevier B.V.
dc.description.sponsorshipThis work was supported by MoH, RF07-ALS. The authors declare no conflict of interest
dc.identifier.citationConti, A., Riva, N., Pesca, M., Iannaccone, S., Cannistraci, C. V., Corbo, M., … Alessio, M. (2014). Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1842(1), 99–106. doi:10.1016/j.bbadis.2013.10.013
dc.identifier.doi10.1016/j.bbadis.2013.10.013
dc.identifier.issn09254439
dc.identifier.journalBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
dc.identifier.pmid24184715
dc.identifier.urihttp://hdl.handle.net/10754/563293
dc.publisherElsevier BV
dc.subjectAmyotrophic lateral sclerosis
dc.subjectMyosin binding protein H
dc.subjectSkeletal muscle
dc.titleIncreased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients
dc.typeArticle
display.details.left<span><h5>Type</h5>Article<br><br><h5>Authors</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Conti, Antonio,equals">Conti, Antonio</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Riva, Nilo,equals">Riva, Nilo</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Pesca, Mariasabina Sabina,equals">Pesca, Mariasabina Sabina</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Iannaccone, Sandro,equals">Iannaccone, Sandro</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Cannistraci, Carlo,equals">Cannistraci, Carlo</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Corbo, Massimo,equals">Corbo, Massimo</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Previtali, Stefano Carlo,equals">Previtali, Stefano Carlo</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Quattrini, Angelo,equals">Quattrini, Angelo</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Alessio, Massimo,equals">Alessio, Massimo</a><br><br><h5>KAUST Department</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Applied Mathematics and Computational Science Program,equals">Applied Mathematics and Computational Science Program</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Integrative Systems Biology Lab,equals">Integrative Systems Biology Lab</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Computational Bioscience Research Center (CBRC),equals">Computational Bioscience Research Center (CBRC)</a><br><br><h5>Date</h5>2014-01</span>
display.details.right<span><h5>Abstract</h5>Amyotrophic lateral sclerosis (ALS) is a severe and fatal neurodegenerative disease of still unknown pathogenesis. Recent findings suggest that the skeletal muscle may play an active pathogenetic role. To investigate ALS's pathogenesis and to seek diagnostic markers, we analyzed skeletal muscle biopsies with the differential expression proteomic approach. We studied skeletal muscle biopsies from healthy controls (CN), sporadic ALS (sALS), motor neuropathies (MN) and myopathies (M). Pre-eminently among several differentially expressed proteins, Myosin binding protein H (MyBP-H) expression in ALS samples was anomalously high. MyBP-H is a component of the thick filaments of the skeletal muscle and has strong affinity for myosin, but its function is still unclear. High MyBP-H expression level was associated with abnormal expression of Rho kinase 2 (ROCK2), LIM domain kinase 1 (LIMK1) and cofilin2, that might affect the actin-myosin interaction. We propose that MyBP-H expression level serves, as a putative biomarker in the skeletal muscle, to discriminate ALS from motor neuropathies, and that it signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of ALS. © 2013 Elsevier B.V.<br><br><h5>Citation</h5>Conti, A., Riva, N., Pesca, M., Iannaccone, S., Cannistraci, C. V., Corbo, M., … Alessio, M. (2014). Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1842(1), 99–106. doi:10.1016/j.bbadis.2013.10.013<br><br><h5>Acknowledgements</h5>This work was supported by MoH, RF07-ALS. The authors declare no conflict of interest<br><br><h5>Publisher</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.publisher=Elsevier BV,equals">Elsevier BV</a><br><br><h5>Journal</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.journal=Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,equals">Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease</a><br><br><h5>DOI</h5><a href="https://doi.org/10.1016/j.bbadis.2013.10.013">10.1016/j.bbadis.2013.10.013</a><br><br><h5>PubMed ID</h5><a href="https://www.ncbi.nlm.nih.gov/pubmed/24184715">24184715</a></span>
kaust.personCannistraci, Carlo
orcid.authorConti, Antonio
orcid.authorRiva, Nilo
orcid.authorPesca, Mariasabina Sabina
orcid.authorIannaccone, Sandro
orcid.authorCannistraci, Carlo
orcid.authorCorbo, Massimo
orcid.authorPrevitali, Stefano Carlo
orcid.authorQuattrini, Angelo
orcid.authorAlessio, Massimo
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