Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds

dc.contributor.authorWang, Kai-Ling
dc.contributor.authorXu, Ying
dc.contributor.authorLu, Liang
dc.contributor.authorLi, Yongxin
dc.contributor.authorHan, Zhuang
dc.contributor.authorZhang, Jun
dc.contributor.authorShao, Chang-Lun
dc.contributor.authorWang, Chang-Yun
dc.contributor.authorQian, Pei-Yuan
dc.contributor.institutionOcean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China
dc.contributor.institutionHong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay, Hong Kong, Peoples R China
dc.contributor.institutionShenzhen Univ, Coll Life Sci, Shenzhen 518060, Peoples R China
dc.contributor.institutionHong Kong Univ Sci & Technol, Environm Sci Program, Sch Sci, Clear Water Bay, Hong Kong, Peoples R China
dc.contributor.institutionChinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China
dc.contributor.institutionJinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
dc.date.accessioned2021-11-01T08:47:46Z
dc.date.available2021-11-01T08:47:46Z
dc.date.issued2015
dc.description.abstractIn the present study, eight natural products that belonged to di(1H-indol-3-yl)methane (DIM) family were isolated from Pseudovibrio denitrificans UST4-50 and tested for their antifouling activity against larval settlement (including both attachment and metamorphosis) of the barnacle Balanus (=Amphibalanus) amphitrite and the bryozoan Bugula neritina. All diindol-3-ylmethanes (DIMs) showed moderate to strong inhibitory effects against larval settlement of B. amphitrite with EC<inf>50</inf> values ranging from 18.57 to 1.86 μM and could be considered as low-toxicity antifouling compounds since their LC<inf>50</inf>/EC<inf>50</inf> ratios were larger than 15. Furthermore, the DIM- and 4-(di(1H-indol-3-yl)methyl)phenol (DIM-Ph-4-OH)-treated larvae completed normal settlement when they were transferred to clean seawater after being exposed to those compounds for 24 h. DIM also showed comparable antifouling performance to the commercial antifouling biocide Sea-Nine 211™ in the field test over a period of 5 months, which further confirmed that DIMs can be considered as promising candidates of environmentally friendly antifouling compounds.
dc.description.sponsorshipWe thank Dr. Paul J. Muller from the King Abdullah University of Science and Technology (KAUST) for helping us collect the tunicates. This study was supported by a grant from China Ocean Mineral Resources Research and Development (DY125-15-T-02), a Strategic Priority Research Program of CAS (XDB06010102), a grant from 863 Program (No.2012AA092103), an award (SA-C0040/UK-C0016) from KAUST, and the National Natural Science Foundation of China (Nos. 41130858; 41322037).
dc.identifier.citationWang, K.-L., Xu, Y., Lu, L., Li, Y., Han, Z., Zhang, J., … Qian, P.-Y. (2015). Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. Marine Biotechnology, 17(5), 624–632. doi:10.1007/s10126-015-9656-6
dc.identifier.doi10.1007/s10126-015-9656-6
dc.identifier.eid2-s2.0-84939571290
dc.identifier.issn1436-2236
dc.identifier.issn1436-2228
dc.identifier.issue5
dc.identifier.journalMARINE BIOTECHNOLOGY
dc.identifier.pages624-632
dc.identifier.urihttp://hdl.handle.net/10754/673041
dc.identifier.volume17
dc.identifier.wosutWOS:000359948100008
dc.publisherSPRINGER
dc.relation.urlhttp://link.springer.com/10.1007/s10126-015-9656-6
dc.subjectBiofouling
dc.subjectLow-toxicity antifouling compounds
dc.subjectDiindol-3-ylmethane
dc.subjectPseudovibrio
dc.titleLow-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds
dc.typeArticle
display.details.left<span><h5>Type</h5>Article<br><br><h5>Authors</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Wang, Kai-Ling,equals">Wang, Kai-Ling</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Xu, Ying,equals">Xu, Ying</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Lu, Liang,equals">Lu, Liang</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Li, Yongxin,equals">Li, Yongxin</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Han, Zhuang,equals">Han, Zhuang</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Zhang, Jun,equals">Zhang, Jun</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Shao, Chang-Lun,equals">Shao, Chang-Lun</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Wang, Chang-Yun,equals">Wang, Chang-Yun</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Qian, Pei-Yuan,equals">Qian, Pei-Yuan</a><br><br><h5>KAUST Grant Number</h5>SA-C0040/UK-C0016<br><br><h5>Date</h5>2015</span>
display.details.right<span><h5>Abstract</h5>In the present study, eight natural products that belonged to di(1H-indol-3-yl)methane (DIM) family were isolated from Pseudovibrio denitrificans UST4-50 and tested for their antifouling activity against larval settlement (including both attachment and metamorphosis) of the barnacle Balanus (=Amphibalanus) amphitrite and the bryozoan Bugula neritina. All diindol-3-ylmethanes (DIMs) showed moderate to strong inhibitory effects against larval settlement of B. amphitrite with EC<inf>50</inf> values ranging from 18.57 to 1.86 μM and could be considered as low-toxicity antifouling compounds since their LC<inf>50</inf>/EC<inf>50</inf> ratios were larger than 15. Furthermore, the DIM- and 4-(di(1H-indol-3-yl)methyl)phenol (DIM-Ph-4-OH)-treated larvae completed normal settlement when they were transferred to clean seawater after being exposed to those compounds for 24 h. DIM also showed comparable antifouling performance to the commercial antifouling biocide Sea-Nine 211™ in the field test over a period of 5 months, which further confirmed that DIMs can be considered as promising candidates of environmentally friendly antifouling compounds.<br><br><h5>Citation</h5>Wang, K.-L., Xu, Y., Lu, L., Li, Y., Han, Z., Zhang, J., … Qian, P.-Y. (2015). Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. Marine Biotechnology, 17(5), 624–632. doi:10.1007/s10126-015-9656-6<br><br><h5>Acknowledgements</h5>We thank Dr. Paul J. Muller from the King Abdullah University of Science and Technology (KAUST) for helping us collect the tunicates. This study was supported by a grant from China Ocean Mineral Resources Research and Development (DY125-15-T-02), a Strategic Priority Research Program of CAS (XDB06010102), a grant from 863 Program (No.2012AA092103), an award (SA-C0040/UK-C0016) from KAUST, and the National Natural Science Foundation of China (Nos. 41130858; 41322037).<br><br><h5>Publisher</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.publisher=SPRINGER,equals">SPRINGER</a><br><br><h5>Journal</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.journal=MARINE BIOTECHNOLOGY,equals">MARINE BIOTECHNOLOGY</a><br><br><h5>DOI</h5><a href="https://doi.org/10.1007/s10126-015-9656-6">10.1007/s10126-015-9656-6</a><br><br><h5>Additional Links</h5>http://link.springer.com/10.1007/s10126-015-9656-6</span>
kaust.grant.numberSA-C0040/UK-C0016
orcid.authorWang, Kai-Ling
orcid.authorXu, Ying
orcid.authorLu, Liang
orcid.authorLi, Yongxin
orcid.authorHan, Zhuang
orcid.authorZhang, Jun
orcid.authorShao, Chang-Lun
orcid.authorWang, Chang-Yun
orcid.authorQian, Pei-Yuan
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