Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels

dc.contributor.affiliationKing Abdullah University of Science and Technology (KAUST)
dc.contributor.authorShi, Junfeng
dc.contributor.authorYuan, Dan
dc.contributor.authorHaburcak, Richard
dc.contributor.authorZhang, Qiang
dc.contributor.authorZhao, Chao
dc.contributor.authorZhang, Xixiang
dc.contributor.authorXu, Bing
dc.contributor.departmentImaging and Characterization Core Lab
dc.contributor.departmentMaterial Science and Engineering Program
dc.contributor.departmentNanofabrication Core Lab
dc.contributor.departmentPhysical Characterization
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentThin Films & Characterization
dc.contributor.institutionDepartment of Chemistry; Brandeis University; Waltham UNITED STATES
dc.date.accessioned2015-10-20T09:53:12Z
dc.date.available2015-10-20T09:53:12Z
dc.date.issued2015-10-29
dc.date.published-online2015-10-29
dc.date.published-print2015-12-07
dc.description.abstractEnzyme-catalyzed dephosphorylation is essential for biomineralization and bone metabolism. Here we report the exploration of using enzymatic reaction to transform biocomposites of phosphopeptides and calcium (or strontium) ions to supramolecular hydrogels as a mimic of enzymatic dissolution of biominerals. 31P NMR shows that strong affinity between the phosphopeptides and alkaline metal ions (e.g., Ca2+ or Sr2+) induces the formation of biocomposites as precipitates. Electron microscopy reveals that the enzymatic reaction regulates the morphological transition from particles to nanofibers. Rheology confirms the formation of a rigid hydrogel. As the first example of enzyme-instructed dissolution of a solid to form supramolecular nanofibers/hydrogels, this work provides an approach to generate soft materials with desired properties, expands the application of supramolecular hydrogelators, and offers insights to control the demineralization of calcified soft tissues.
dc.eprint.versionPost-print
dc.identifier.citationEnzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels 2015:n/a Chemistry - A European Journal
dc.identifier.doi10.1002/chem.201504087
dc.identifier.issn09476539
dc.identifier.journalChemistry - A European Journal
dc.identifier.pmid26462722
dc.identifier.urihttp://hdl.handle.net/10754/579911
dc.language.isoen
dc.publisherWiley
dc.relation.urlhttp://doi.wiley.com/10.1002/chem.201504087
dc.rightsThis is the peer reviewed version of the following article: Shi, Junfeng, Dan Yuan, Richard Haburcak, Qiang Zhang, Chao Zhao, Xixiang Zhang, and Bing Xu. "Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels." Chemistry-A European Journal (2015)., which has been published in final form at http://doi.wiley.com/10.1002/chem.201504087. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
dc.subjectphosphopeptide
dc.subjectsolid-gel transition
dc.subjectenzyme
dc.subjectself-assembly
dc.subjectbone mineralization
dc.titleEnzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels
dc.typeArticle
display.details.left<span><h5>Type</h5>Article<br><br><h5>Authors</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Shi, Junfeng,equals">Shi, Junfeng</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Yuan, Dan,equals">Yuan, Dan</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Haburcak, Richard,equals">Haburcak, Richard</a><br><a href="https://repository.kaust.edu.sa/search?query=orcid.id:0000-0001-8519-5158&spc.sf=dc.date.issued&spc.sd=DESC">Zhang, Qiang</a> <a href="https://orcid.org/0000-0001-8519-5158" target="_blank"><img src="https://repository.kaust.edu.sa/server/api/core/bitstreams/82a625b4-ed4b-40c8-865a-d6a5225a26a4/content" width="16" height="16"/></a><br><a href="https://repository.kaust.edu.sa/search?query=orcid.id:0000-0002-9582-1068&spc.sf=dc.date.issued&spc.sd=DESC">Zhao, Chao</a> <a href="https://orcid.org/0000-0002-9582-1068" target="_blank"><img src="https://repository.kaust.edu.sa/server/api/core/bitstreams/82a625b4-ed4b-40c8-865a-d6a5225a26a4/content" width="16" height="16"/></a><br><a href="https://repository.kaust.edu.sa/search?query=orcid.id:0000-0002-3478-6414&spc.sf=dc.date.issued&spc.sd=DESC">Zhang, Xixiang</a> <a href="https://orcid.org/0000-0002-3478-6414" target="_blank"><img src="https://repository.kaust.edu.sa/server/api/core/bitstreams/82a625b4-ed4b-40c8-865a-d6a5225a26a4/content" width="16" height="16"/></a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.author=Xu, Bing,equals">Xu, Bing</a><br><br><h5>KAUST Department</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Imaging and Characterization Core Lab,equals">Imaging and Characterization Core Lab</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Material Science and Engineering Program,equals">Material Science and Engineering Program</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Nanofabrication Core Lab,equals">Nanofabrication Core Lab</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Physical Characterization,equals">Physical Characterization</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Physical Science and Engineering (PSE) Division,equals">Physical Science and Engineering (PSE) Division</a><br><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.department=Thin Films & Characterization,equals">Thin Films & Characterization</a><br><br><h5>Online Publication Date</h5>2015-10-29<br><br><h5>Print Publication Date</h5>2015-12-07<br><br><h5>Date</h5>2015-10-29</span>
display.details.right<span><h5>Abstract</h5>Enzyme-catalyzed dephosphorylation is essential for biomineralization and bone metabolism. Here we report the exploration of using enzymatic reaction to transform biocomposites of phosphopeptides and calcium (or strontium) ions to supramolecular hydrogels as a mimic of enzymatic dissolution of biominerals. 31P NMR shows that strong affinity between the phosphopeptides and alkaline metal ions (e.g., Ca2+ or Sr2+) induces the formation of biocomposites as precipitates. Electron microscopy reveals that the enzymatic reaction regulates the morphological transition from particles to nanofibers. Rheology confirms the formation of a rigid hydrogel. As the first example of enzyme-instructed dissolution of a solid to form supramolecular nanofibers/hydrogels, this work provides an approach to generate soft materials with desired properties, expands the application of supramolecular hydrogelators, and offers insights to control the demineralization of calcified soft tissues.<br><br><h5>Citation</h5>Enzymatic Dissolution of Biocomposite Solids Consisting of Phosphopeptides to Form Supramolecular Hydrogels 2015:n/a Chemistry - A European Journal<br><br><h5>Publisher</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.publisher=Wiley,equals">Wiley</a><br><br><h5>Journal</h5><a href="https://repository.kaust.edu.sa/search?spc.sf=dc.date.issued&spc.sd=DESC&f.journal=Chemistry - A European Journal,equals">Chemistry - A European Journal</a><br><br><h5>DOI</h5><a href="https://doi.org/10.1002/chem.201504087">10.1002/chem.201504087</a><br><br><h5>PubMed ID</h5><a href="https://www.ncbi.nlm.nih.gov/pubmed/26462722">26462722</a><br><br><h5>Additional Links</h5>http://doi.wiley.com/10.1002/chem.201504087</span>
kaust.personZhang, Qiang
kaust.personZhao, Chao
kaust.personZhang, Xixiang
orcid.authorShi, Junfeng
orcid.authorYuan, Dan
orcid.authorHaburcak, Richard
orcid.authorZhang, Qiang::0000-0001-8519-5158
orcid.authorZhao, Chao::0000-0002-9582-1068
orcid.authorZhang, Xixiang::0000-0002-3478-6414
orcid.authorXu, Bing
orcid.id0000-0002-3478-6414
orcid.id0000-0002-9582-1068
orcid.id0000-0001-8519-5158
refterms.dateFOA2016-10-14T00:00:00Z
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