McClintock's challenge in the 21st century

Type
Article

Authors
Fedoroff, Nina V.

KAUST Department
Biological and Environmental Science and Engineering (BESE) Division
Bioscience Program
Center for Desert Agriculture

Online Publication Date
2012-11-13

Print Publication Date
2012-12-11

Date
2012-11-13

Abstract
In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.

Citation
Fedoroff, N. V. (2012). McClintock’s challenge in the 21st century. Proceedings of the National Academy of Sciences, 109(50), 20200–20203. doi:10.1073/pnas.1215482109

Publisher
Proceedings of the National Academy of Sciences

Journal
Proceedings of the National Academy of Sciences

DOI
10.1073/pnas.1215482109

PubMed ID
23150590

PubMed Central ID
PMC3528499

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