Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling

Abstract
The cyclic nucleotide monophosphates (cNMPs), and notably 3′,5′-cyclic guanosine monophosphate (cGMP) and 3′,5′-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic defense. At the single molecule level, we are now beginning to understand how cNMPs modify specific target molecules such as cyclic nucleotide-gated channels, while at the systems level, a recent study of the Arabidopsis cNMP interactome has identified novel target molecules with specific cNMP-binding domains. A major advance came with the discovery and characterization of a steadily increasing number of guanylate cyclases (GCs) and adenylate cyclases (ACs). Several of the GCs are receptor kinases and include the brassinosteroid receptor, the phytosulfokine receptor, the Pep receptor, the plant natriuretic peptide receptor as well as a nitric oxide sensor. We foresee that in the near future many more molecular mechanisms and biological roles of GCs and ACs and their catalytic products will be discovered and further establish cNMPs as a key component of plant responses to the environment.

Citation
Gehring C, Turek IS (2017) Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling. Frontiers in Plant Science 8. Available: http://dx.doi.org/10.3389/fpls.2017.01704.

Acknowledgements
The cost for the publication of this article was covered by King Abdullah University of Science and Technology.

Publisher
Frontiers Media SA

Journal
Frontiers in Plant Science

DOI
10.3389/fpls.2017.01704

PubMed ID
29046682

Additional Links
https://www.frontiersin.org/articles/10.3389/fpls.2017.01704/full

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