In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit

Abstract
Water-based suspension of silver nanoparticles (AgNPs) and dextran coated AgNPs (dextran-AgNPs) are fabricated and characterised for intravenous administration. A simple method for radiolabelling of nanoparticles with 99mTc was used. Labelling efficiency for AgNPs and dextran-AgNPs was found to be more than 80 and 88%, respectively. In vivo tissue uptake of nanoparticles during dynamic phase, after systematic administration by biodistribution analysis with single-photon emission computed tomography imaging has been evaluated. Biodistribution analysis revealed that 99mTc-AgNPs and 99mTc-dextran-AgNPs are mainly accumulated in liver/spleen region but 99mTc-dextran-AgNPs delayed recognition and uptake by liver. Results indicate that dextran-AgNPs are able to evade reticuloendothelum system with enhanced blood retention time. Accumulation of nanoparticles in liver/spleen region implicates the utilisation of AgNPs for liver cancer treatment. © 2015 The Institution of Engineering and Technology.

Citation
Ashraf, A., Sharif, R., Ahmad, M., Masood, M., Shahid, A., Anjum, D. H., Rafique, M. S., & Ghani, S. (2015). In vivo evaluation of the biodistribution of intravenously administered naked and functionalised silver nanoparticles in rabbit. IET Nanobiotechnology, 9(6), 368–374. Portico. https://doi.org/10.1049/iet-nbt.2014.0075

Publisher
Institution of Engineering and Technology (IET)

Journal
IET Nanobiotechnology

DOI
10.1049/iet-nbt.2014.0075

PubMed ID
26647813

Permanent link to this record