Estimation of the neuronal activation using fMRI data: An observer-based approach

Abstract
This paper deals with the estimation of the neuronal activation and some unmeasured physiological information using the Blood Oxygenation Level Dependent (BOLD) signal measured using functional Magnetic Resonance Imaging (fMRI). We propose to use an observer-based approach applied to the balloon hemodynamic model. The latter describes the relation between the neural activity and the BOLD signal. The balloon model can be expressed in a nonlinear state-space representation where the states, the parameters and the input (neuronal activation), are unknown. This study focuses only on the estimation of the hidden states and the neuronal activation. The model is first linearized around the equilibrium and an observer is applied to this linearized version. Numerical results performed on synthetic data are presented.

Citation
Laleg Kirati, T. M., Arabi, H., Tadjine, M., & Zayane, C. (2013). Estimation of the neuronal activation using fMRI data: An observer-based approach. 2013 American Control Conference. doi:10.1109/acc.2013.6580691

Publisher
Institute of Electrical and Electronics Engineers (IEEE)

Journal
2013 American Control Conference

Conference/Event Name
2013 1st American Control Conference, ACC 2013

DOI
10.1109/acc.2013.6580691

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