Beyond the Symptom: The Biology of Fatigue.

Abstract
A workshop titled "Beyond the Symptom: The Biology of Fatigue" was held virtually September 27-28, 2021. It was jointly organized by the Sleep Research Society and the Neurobiology of Fatigue Working Group of the NIH Blueprint Neuroscience Research Program. For access to the presentations and video recordings, see: https : //neuroscienceblueprint.nih.gov/about/event/beyond-symptom-biology-fatigue. The goals of this workshop were to bring together clinicians and scientists who use a variety of research approaches to understand fatigue in multiple conditions and to identify key gaps in our understanding of the biology of fatigue. This workshop summary distills key issues discussed in this workshop and provides a list of promising directions for future research on this topic. We do not attempt to provide a comprehensive review of the state of our understanding of fatigue, nor to provide a comprehensive reprise of the many excellent presentations. Rather, our goal is to highlight key advances and to focus on questions and future approaches to answering them.

Citation
Raizen, D. M., Mullington, J., Anaclet, C., Clarke, G., Critchley, H., Dantzer, R., Davis, R., Drew, K. L., Fessel, J., Fuller, P. M., Gibson, E. M., Harrington, M., Lipkin, W. I., Klerman, E. B., Klimas, N., Komaroff, A. L., Koroshetz, W., Krupp, L., Kuppuswamy, A., … Heller, H. C. (2023). Beyond the Symptom: The Biology of Fatigue. SLEEP. https://doi.org/10.1093/sleep/zsad069

Acknowledgements
This report was written by experts who attended and presented at the workshop. Opinions expressed by the authors, however, do not represent the policy or position of the NIH. We are grateful to the NIH Blueprint Neuroscience Research Program for their financial support of the workshop. David M Raizen is funded by the National Institute of Neurological Disease and Stroke (NINDS) of the National Institutes of Health (NIH) under award number: R01NS122779 and by a Department of Defense (DoD) under award number W81XWH-22-1-0069. Janet Mullington is funded by the National Heart, Lung, and Blood Institute (NHLBI) of the NIH under award number: R01HL125379. C Anaclet has no Financial or Non-Financial Disclosures; she is funded by NINDS of the NIH under award number: R01NS073613 and by the BrightFocus Foundation. Christelle Anaclet is funded by NINDS of the NIH under award number: R01NS073613 and by the BrightFocus Foundation. Robert Dantzer is funded by the National Cancer Institute (NCI) of the NIH under award number: R01 CA193522. Ron Davis receives funding from the Open Medicine Foundation, the ARPA Foundation, donations from patients and caregivers, and is funded by the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH under award number: R01AI139550. Kelly L Drew and has received research support from Be Cool Pharmaceutics for work unrelated to this project and is funded by the National Institute of General Medical Sciences (NIGMS) of the NIH under award number: P20GM130443. Patrick M Fuller is funded by NINDS of the NIH under award numbers: R01NS103161 and R01NS073613 and by NHLBI of the NIH under award number: P01HL149630. Erin M Gibson is funded by NCI of the NIH under award number: R21CA267135, by NINDS of the NIH under award number: R01NS126610, and the DoD under award number: W81XWH2110846. Mary Harrington is funded by the NIGMS of the NIH under award number: R15 GM126545. W Ian Lipkin is funded by NIAID of the NIH under award number: U54AI138370-06. Elizabeth B Klerman is funded by NINDS of the NIH under award numbers R01-NS099055, U01-NS114001, R01-NS114526-02S1, by the National Institute of Aging (NIA) of the NIH under award number: U54-AG062322, by the National Institute of Drug Abuse of the NIH under award number R21-DA052861, by the National Institute of Child Health and Human Development (NICHD) of the NIH under award number: R01- HD107064; by the DoD under award number: W81XWH201076; and by the Leducq Trans-Atlantic Network of Excellence On Circadian Effects in Stroke. Anthony L Komaroff is funded by NIAID of the NIH under award number: 1U54AI138370. Anna Kuppuswamy is funded by Wellcome Trust under award number: 202346/Z/16/Z. Lauren D Lewis is funded by NIA of the NIH under award number: R01AG070135, by the National Center for Complementary and Integrative Health (NCCIH) of the NIH under award number: R01AT011429, and by NINDS of the NIH under award number R21NS123412. Maiken Nedergaard is funded by NINDS of the NIH under award numbers: RF1NS110049 and U19NS128613 and by NCCIH of the NIH under award number: R01AT011439. Mark R Opp is funded by the NIA of the NIH under award number: R01AG064465, and by the DoD under award number: W81XXWH221084. Dragana Rogulja is funded by The New York Stem Cell Foundation. A Rolls is funded by the European Research Council (ERC) STG-NEIMO. John D Salamone is funded by the National Institute of Mental Health (NIMH) of the NIH under the award number: R01MH121350, and by Otsuka, and the University of Connecticut Research Foundation. Clifford Saper is funded by NINDS of the NIH under award number: R01 NS072337, by NIMH of the NIH under award number: R01 MH112714, by NHLBI under award number: P01 HL149630, and by a subcontract from the University of Tsukuba, Japan. Glenn Wylie is funded by the Department of Veterans' Affairs under award number: 5I01CX000893, by the National Multiple Sclerosis Society under award number: RG 4232A1, and by the New Jersey Commission for Brain Injury Research under award number: 10.005.BIR1. Jarred Younger is funded by NINDS of the NIH under award number: R01-NS109529, and by the DoD under award number W81XWH-19-1-0725. Phyllis C Zee is funded by NHLBI of the NIH under award number: R01HL140580, by NIA of the NIH under award numbers: P01AG011412, R01AG059291 and R01AG068579, and by NICHD of the NIH under award number: R01HD097786. The workshop was supported by funding from the NIH Blueprint Neuroscience Research Program. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Journal
Sleep

DOI
10.1093/sleep/zsad069

PubMed ID
37224457

Additional Links
https://academic.oup.com/sleep/advance-article/doi/10.1093/sleep/zsad069/7177603

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