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Water-ultrastable perovskite CsPbBr3 nanocrystals for fluorescence-enhanced cellular imaging

dc.contributor.authorHe, Cai Li
dc.contributor.authorMeng, Zi Qi
dc.contributor.authorRen, Shu Xia
dc.contributor.authorLi, Jian
dc.contributor.authorWang, Ye
dc.contributor.authorWu, Hao
dc.contributor.authorBu, Hui
dc.contributor.authorZhang, Yu
dc.contributor.authorHao, Wei Zhong
dc.contributor.authorChen, Shu Lin
dc.contributor.authorYan, Rong Rong
dc.contributor.authorLiu, Huan
dc.contributor.authorZhu, Yu Fang
dc.contributor.authorZhao, Jin Jin
dc.date.accessioned2023-03-06T06:43:27Z
dc.date.available2023-03-06T06:43:27Z
dc.date.issued2023-02-28
dc.identifier.citationHe, C.-L., Meng, Z.-Q., Ren, S.-X., Li, J., Wang, Y., Wu, H., Bu, H., Zhang, Y., Hao, W.-Z., Chen, S.-L., Yan, R.-R., Liu, H., Zhu, Y.-F., & Zhao, J.-J. (2023). Water-ultrastable perovskite CsPbBr3 nanocrystals for fluorescence-enhanced cellular imaging. Rare Metals. https://doi.org/10.1007/s12598-022-02222-8
dc.identifier.issn1867-7185
dc.identifier.issn1001-0521
dc.identifier.doi10.1007/s12598-022-02222-8
dc.identifier.urihttp://hdl.handle.net/10754/690059
dc.description.abstractMetal halide perovskites have attracted much attention in biomedicine because of their excellent fluorescence energy conversion properties; however, poor water-stability and cytotoxicity limit its applications as a biomedical tracer, especially in cellular imaging. Herein, water-ultrastable perovskites CsPbBr3:Cs4PbBr6 nanocrystals (NCs) encapsulated in chitosan are fabricated successfully using a water-triggered method. The as-synthesized CsPbBr3:Cs4PbBr6@CS (chitosan, CS) nanoparticles in water display enhanced fluorescence emission for 35 days. Further, the viability of glioma cells (U87 cells) incubated with different concentrations of CsPbBr3:Cs4PbBr6@CS nanoparticles (0–20 μg·ml−1) for 24 h is found to be higher than 90%. In artificial body fluid, analyses using laser confocal microscopy, the standard Cell Counting Kit-8 (CCK-8) method, and flow cytometry demonstrated the good water ultrastability and high biocompatibility performance of CsPbBr3:Cs4PbBr6@CS nanoparticles in cellular imaging. Overall, the water-ultrastable halide perovskites support promising perspectives in biological cell tracing and intelligent medical technology.
dc.description.sponsorshipThis work was financially supported by the National Natural Science Foundation of China (Nos. U2130128 and 11772207), the Natural Science Foundation of Hebei Province (Nos. A2019210204 and H2022205047), the Central Government Guiding Local Science and Technology Development Project (No. 216Z4302G), the Natural Science Foundation of Hebei Education Department (No. ZD2020192), the Youth Top-notch Talents Supporting Plan of Hebei Province, National Key Research and Development Program of China (No. 2016YFC0904503) and Hebei Administration for Market Supervision Science and Technology Project List (2023ZC03). The authors gratefully acknowledge the Electron Microscopy Laboratory at Peking University for the use of electron microscopes.
dc.publisherSpringer Science and Business Media LLC
dc.relation.urlhttps://link.springer.com/10.1007/s12598-022-02222-8
dc.rightsThis is an accepted manuscript version of a paper before final publisher editing and formatting. Archived with thanks to Springer Science and Business Media LLC. The version of record is available from Rare Metals.
dc.titleWater-ultrastable perovskite CsPbBr3 nanocrystals for fluorescence-enhanced cellular imaging
dc.typeArticle
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.identifier.journalRare Metals
dc.rights.embargodate2024-02-28
dc.eprint.versionPost-print
dc.contributor.institutionInstitute of Materials for Energy Conversion, School of Materials Science and Engineering, Shijiazhuang Tiedao University, Shijiazhuang, 050043, China
dc.contributor.institutionDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China
dc.contributor.institutionGeneral Practice Department, Liaocheng City People’s Hospital, Liaocheng, 252000, China
dc.contributor.institutionTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300000, China
dc.contributor.institutionGeneral Practice Department, Hengshui People’s Hospital, Hengshui, 053000, China
dc.contributor.institutionThe 984th Hospital of the PLA Integrated TCM & Western Medicine Department, Beijing, 100094, China
dc.contributor.institutionState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China
dc.contributor.institutionHebei Key Laboratory of Inorganic Nano-materials, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang, 050024, China
kaust.personChen, Shu Lin
dc.date.accepted2022-09-22
dc.identifier.eid2-s2.0-85149039352


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