Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
Bhagat, Kuber Kumar
Singh, Ankit Kumar
Emwas, Abdul-Hamid M.
KAUST DepartmentSmart-Health Initiative and Red Sea Research Center, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, P.O. Box 4700, Thuwal 23955-6900, Saudi Arabia
King Abdullah University of Science and Technology, Core Labs, Thuwal 23955-6900, Saudi Arabia
Biological and Environmental Science and Engineering (BESE) Division
Red Sea Research Center (RSRC)
Permanent link to this recordhttp://hdl.handle.net/10754/689968
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AbstractCancer is a major cause of deaths across the globe due to chemoresistance and lack of selective chemotherapy. Pyrido[2,3-d]pyrimidine is an emerging scaffold in medicinal chemistry having a broad spectrum of activities, including antitumor, antibacterial, CNS depressive, anticonvulsant, and antipyretic activities. In this study, we have covered different cancer targets, including tyrosine kinase, extracellular regulated protein kinases – ABL kinase, phosphatidylinositol-3 kinase, mammalian target of rapamycin, p38 mitogen-activated protein kinases, BCR-ABL, dihydrofolate reductase, cyclin-dependent kinase, phosphodiesterase, KRAS and fibroblast growth factor receptors, their signaling pathways, mechanism of action and structure–activity relationship of pyrido[2,3-d]pyrimidine derivatives as inhibitors of the above-mentioned targets. This review will represent the complete medicinal and pharmacological profile of pyrido[2,3-d]pyrimidines as anticancer agents, and will help scientists to design new selective, effective and safe anticancer agents.
CitationKumar, A., Bhagat, K. K., Singh, A. K., Singh, H., Angre, T., Verma, A., Khalilullah, H., Jaremko, M., Emwas, A.-H., & Kumar, P. (2023). Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents. RSC Advances, 13(10), 6872–6908. https://doi.org/10.1039/d3ra00056g
SponsorsAuthors are highly thankful to Central University of Punjab, DST-FIST, India, to infrastructural support for completion of this study. The APC was funded by King Abdullah University of Science and Technology (KAUST), Thuwal, Jeddah, Saudi Arabia.
PublisherRoyal Society of Chemistry (RSC)
PubMed Central IDPMC9972360
Except where otherwise noted, this item's license is described as Archived with thanks to RSC advances under a Creative Commons license, details at: http://creativecommons.org/licenses/by/3.0/