Brønsted acid catalyzed enantioselective addition of hydrazones to 3-indolylmethanols
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Article
KAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2022-07-15Permanent link to this record
http://hdl.handle.net/10754/679649Metadata
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The organocatalytic asymmetric addition of hydrazones to indole derivatives in the presence of chiral Brønsted acids is reported. A large variety of substrates are tolerated and the products are obtained in good yields and with excellent enantioselectivities. This metal-free reaction provides a convenient route to enantiopure β-substituted tryptophan derivatives in a concise fashion.Citation
Mader, S., Maji, M. S., Atodiresei, I., & Rueping, M. (2022). Brønsted acid catalyzed enantioselective addition of hydrazones to 3-indolylmethanols. Organic Chemistry Frontiers. https://doi.org/10.1039/d2qo00840hSponsors
The authors acknowledge generous support by KAUST and S. M. thanks the DFG (Deutsche Forschungsgemeinschaft) for financial support through the International Research TrainingGroup SeleCa (IRTG 1628).Publisher
Royal Society of Chemistry (RSC)Journal
Organic Chemistry FrontiersAdditional Links
http://xlink.rsc.org/?DOI=D2QO00840HScopus Count
Except where otherwise noted, this item's license is described as Archived with thanks to Organic Chemistry Frontiers under a Creative Commons license, details at: http://creativecommons.org/licenses/by-nc/3.0/