Sofosbuvir may be a potential anti-sars-cov-2 rdrp drug
| dc.contributor.author | Ibrahim, Mohamed Nabil | |
| dc.contributor.author | Elfiky, Abdo Abdellah | |
| dc.date.accessioned | 2022-06-20T08:19:27Z | |
| dc.date.available | 2022-06-20T08:19:27Z | |
| dc.date.issued | 2021-05-10 | |
| dc.identifier.citation | Ibrahim, M. N., & Elfiky, A. A. (2021). Sofosbuvir May be a Potential Anti-SARS-CoV-2 RdRp Drug. American Journal of Biochemistry and Biotechnology, 17(2), 205–207. doi:10.3844/ajbbsp.2021.205.207 | |
| dc.identifier.issn | 1558-6332 | |
| dc.identifier.issn | 1553-3468 | |
| dc.identifier.doi | 10.3844/ajbbsp.2021.205.207 | |
| dc.identifier.uri | http://hdl.handle.net/10754/679205 | |
| dc.description.abstract | The Coronavirus Diseases 2019 (COVID-19) seriously affecting human health all over the world. More than 107 M people are reported positive for SARS-CoV-2, the virus causing COVID-19 pneumonia, from which +2.3 M died. Nucleotide Inhibitors (NI) have promising results in terms of its efficacy against different viral polymerases, including the Hepatitis C Virus (HCV) Non-Structural Protein 5 B (NS5B) RNA dependent RNA polymerase (RdRp) 1. Thus, the non-structural protein 12 (nsp12) RdRp of the human coronavirus represents an attractive target to develop a possible therapeutic agent. Sofosbuvir proved itself as a potential anti-SARS-CoV-2 RdRp and could inhibit viral replication and infection propagation. | |
| dc.description.sponsorship | Computational support from the King Abdullah University of Science and Technology (KAUST HPC allocation grant “K1482”) and COVID-19 Grant by Cairo University , is acknowledged. | |
| dc.publisher | Science Publications | |
| dc.relation.url | https://thescipub.com/abstract/10.3844/ajbbsp.2021.205.207 | |
| dc.title | Sofosbuvir may be a potential anti-sars-cov-2 rdrp drug | |
| dc.type | Article | |
| dc.identifier.journal | American Journal of Biochemistry and Biotechnology | |
| dc.contributor.institution | Department of Clinical Laboratory Sciences, Jouf University, Saudi Arabia | |
| dc.contributor.institution | Department of Microbiology, Ain Shams University, Egypt | |
| dc.contributor.institution | Department of Biophysics, Cairo University, Egypt | |
| dc.identifier.volume | 17 | |
| dc.identifier.issue | 2 | |
| dc.identifier.pages | 205-207 | |
| dc.identifier.eid | 2-s2.0-85107233257 | |
| kaust.acknowledged.supportUnit | KAUST HPC allocation grant “K1482 |