A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat
Permanent link to this recordhttp://hdl.handle.net/10754/678678
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AbstractAchieving rapid definitive hemostasis is essential to ensure survival of patients with massive bleeding in pre-hospital care. It is however challenging to develop hemostatic agents or dressings that simultaneously deliver a fast, long-lasting and safe treatment of hemorrhage. Here, we integrate meso-/micro-porosity, blood coagulation and stability into a flexible zeolite-cotton hybrid hemostat. We employ an on-site template-free growth route that tightly binds mesoporous single-crystal chabazite zeolite onto the surface of cotton fibers. This hemostatic material maintains high procoagulant activity after water flow treatment. Chabazite particles are firmly anchored onto the cotton surface with < 1% leaching after 10 min of sonication. The as-synthesized hemostatic device has superior hemostatic performance over most other clay or zeolite-based inorganic hemostats, in terms of higher procoagulant activity, minimized loss of active components and better scalability for practical applications (a hemostatic T-shirt is hereby demonstrated as an example).
CitationYu, L., Shang, X., Chen, H., Xiao, L., Zhu, Y., & Fan, J. (2019). A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat. Nature Communications, 10(1). doi:10.1038/s41467-019-09849-9
SponsorsThis work was supported by National Natural Science Foundation of China (91545113, 91845203), China Postdoctoral Science Foundation (2017M610363, 2018T110584), Shell Global Solutions International B. V. (PT71423, PT74557), Fok Ying Tong Education Foundation (131015), and the Science & Technology Program of Ningbo (2017C50014). Y. Zhu acknowledges the financial support from the National Natural Science Foundation of China (Grant no. 21771161), the Thousand Talents Program for Distinguished Young Scholars and KAUST Visiting Researcher Scholar. We thank Dr. Zhangxiong Wu for for helpful discussion.
PubMed Central IDPMC6488602
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