The emerging link between cancer, metabolism, and circadian rhythms

Type
Article
Authors
Masri, Selma
Sassone-Corsi, Paolo
Date
2018-12-06
Permanent link to this record
http://hdl.handle.net/10754/678635

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Abstract
The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
Citation
Masri, S., & Sassone-Corsi, P. (2018). The emerging link between cancer, metabolism, and circadian rhythms. Nature Medicine, 24(12), 1795–1803. doi:10.1038/s41591-018-0271-8
Sponsors
The Masri laboratory is supported by a K22 Transition Career Development Award through the National Cancer Institute (NCI), the Concern Foundation, and the V Foundation for Cancer Research. Work in the Sassone-Corsi laboratory is supported by NIH (National Institutes of Health), INSERM (Institut National de la Sante et la Recherche Medicale, France), and KAUST (King Abdullah University of Science and Technology, Saudi Arabia).
Publisher
NATURE RESEARCH
Journal
NATURE MEDICINE
DOI
10.1038/s41591-018-0271-8
PubMed ID
30523327
PubMed Central ID
PMC6535395
Additional Links
http://www.nature.com/articles/s41591-018-0271-8
Collections
Publications Acknowledging KAUST Support