Aza-ortho-Quinone Methides as Reactive Intermediates: Generation and Utility in Contemporary Asymmetric Synthesis
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Chemistry A European J - 2022 - Liao - Aza‐ortho‐Quinone Methides as Reactive Intermediates Generation and Utility in_removed.pdf
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ArticleKAUST Department
King Abdullah University of Science and Technology, KAUST Catalysis Center (KCC) SAUDI ARABIAKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Chemical Science Program
Date
2022-06-02Embargo End Date
2023-06-02Permanent link to this record
http://hdl.handle.net/10754/678592
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The aza- ortho -quinone methide (aza- o -QM) chemistry has overwhelmingly progressed in the past few decades. This review aims to integrate various transition metal-catalyzed and organocatalytic strategies in taming aza -o- QM intermediates, including its the aza- para -quinone methide (aza- p -QM), aza- ortho -vinylidene quinone methide (aza- o -VQM), aza- ortho -alkynyl quinone methide (aza- o -AQM), and indole-based aza- o -QM analogs. These transient species are often utilized for the direct and enantioselective synthesis of complex (hetero)polycyclic or fused-ring molecular scaffolds such as tetrahydroquinoline and indoline, among others, which are abundant in many natural products, bioactive compounds, and pharmaceuticals.Citation
Liao, H.-H., Miñoza, S., Lee, S.-C., & Rueping, M. (2022). Aza-ortho-Quinone Methides as Reactive Intermediates: Generation and Utility in Contemporary Asymmetric Synthesis. Chemistry – A European Journal. Portico. https://doi.org/10.1002/chem.202201112Sponsors
Dr. Hsuan-HungLiao expresses his gratitude to the Young Scholar Fellowship Program of Ministry of Science and Technology (MOST110-2636-M-110-003) and Yushan Young Scholar Program of Ministry of Education (MOE) in Taiwan for their financial support. Shinje Miñoza also thanks National Sun Yat-sen University(NSYSU) Scholarship. The authors are thankful for Heng-Bo Lin (NSYSU), Joshua Andrew P. Nillama (Mindanao State University –Iligan Institute of Technology), and Ivy L. Librando (University of Lisbon) for proofreading this review.Publisher
WileyJournal
Chemistry – A European JournalPubMed ID
35652815Additional Links
https://onlinelibrary.wiley.com/doi/10.1002/chem.202201112ae974a485f413a2113503eed53cd6c53
10.1002/chem.202201112
Scopus Count
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