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dc.contributor.authorAltowairki, Hanan
dc.contributor.authorBasingab, Fatemah S.
dc.contributor.authorAbdullah, Samaa T.
dc.contributor.authorHussein, Mahmoud A.
dc.contributor.authorHadjichristidis, Nikos
dc.contributor.authorAlkayal, Nazeeha
dc.date.accessioned2022-05-12T06:38:31Z
dc.date.available2022-05-12T06:38:31Z
dc.date.issued2022-05-11
dc.identifier.citationAltowairki, H., Basingab, F. S., Abdullah, S. T., Hussein, M. A., Hadjichristidis, N., & Alkayal, N. S. (2022). New cross-linked poly(methyl methacrylate): Synthesis, characterization, and inhibitory effects against selected bacteria and cancer cells. Polymer Engineering & Science. Portico. https://doi.org/10.1002/pen.26009
dc.identifier.issn0032-3888
dc.identifier.issn1548-2634
dc.identifier.doi10.1002/pen.26009
dc.identifier.urihttp://hdl.handle.net/10754/676860
dc.description.abstractNovel cross-linked poly(methyl methacrylate) (PMMA) derivatives with different ratios of crosslinkers (2, 5, 10, 20, 30, 40, and 50 wt%) were synthesized using the condensation method between PMMA and bifunctional amino derivative cross-linkers, o-phenylenediamine (OPD), and m-phenylenediamine (MPD). The final products were tested for antibacterial and anticancer activities. Various techniques were used to characterize the cross-linked polymers. Fourier transform infrared (FTIR) spectroscopy was used to identify interactions between PMMA and diamine derivatives. The scanning electron microscope (SEM) images show that the smooth PMMA surface was totally changed after cross-linking. Thermogravimetric analysis (TGA) results show that when the percentage of cross-linked PMMA (C-PMMA) increased, the decomposition temperature at 25%, 50%, and 75% weight loss increased. C-PMMA/2% OPD, C-PMMA/20% OPD, and C-PMMA/20% MPD have an antibacterial effect on both Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) with an inhibitory zone ranged from 9 to 16 mm. In addition, C-PMMA/2% OPD showed anticancer activities, reducing the number of HepG2 cancer cells significantly. A positive correlation between the concentrations of the product and the reduction of HepG2 cells has been detectedr.
dc.description.sponsorshipSupported by King Abdullah University of Science and Technology (KAUST), and King Abdulaziz University, Saudi Arabia
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1002/pen.26009
dc.rightsArchived with thanks to Polymer Engineering & Science
dc.titleNew cross-linked poly(methyl methacrylate): Synthesis, characterization, and inhibitory effects against selected bacteria and cancer cells
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalPolymer Engineering & Science
dc.rights.embargodate2023-05-11
dc.eprint.versionPost-print
dc.contributor.institutionChemistry Department, Faculty of Science King Abdulaziz University Jeddah Saudi Arabia
dc.contributor.institutionDepartment of Biological Sciences King Abdulaziz University Jeddah Saudi Arabia
dc.contributor.institutionImmunology Unit, King Fahad for Medical Research King Abdulaziz University Jeddah Saudi Arabia
dc.contributor.institutionPolymer Chemistry Lab, Chemistry Department Assiut University Assiut Egypt
kaust.personHadjichristidis, Nikos


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