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dc.contributor.authorRachmaniah, Orchidea
dc.contributor.authorWilson, Erica
dc.contributor.authorChoi, Young Hae
dc.contributor.authorWitkamp, Geert Jan
dc.contributor.authorVerpoorte, Robert
dc.date.accessioned2022-04-21T08:46:54Z
dc.date.available2022-04-21T08:46:54Z
dc.date.issued2022-03-18
dc.identifier.citationRachmaniah, O., Wilson, E., Choi, Y. H., Witkamp, G.-J., & Verpoorte, R. (2022). Pressurized Natural Deep Eutectic Solvent Extraction of Galanthamine and related alkaloids from Narcissus pseudonarcissus. Planta Medica. CLOCKSS. https://doi.org/10.1055/a-1803-3259
dc.identifier.issn0032-0943
dc.identifier.issn1439-0221
dc.identifier.pmid35304734
dc.identifier.doi10.1055/a-1803-3259
dc.identifier.urihttp://hdl.handle.net/10754/676405
dc.description.abstractThe isolation of a compound from a natural source involves many organic and mostly toxic solvents for extraction and purification. Natural Deep Eutectic Solvents (NADES) have been shown to be efficient options for the extraction of natural products. They have the advantage of being composed of abundantly available common primary metabolites, being non-toxic and environmentally safe solvents. The aim of this study was to develop a NADES-based extraction method for galanthamine, an important therapeutic agent for the treatment of Alzheimer’s disease. This alkaloid can be produced by synthesis or by extraction from Narcissus bulbs. To develop an efficient extraction method a number of different NADES was first tested for their solubilization capacity of the galanthamine bromide salt. Promising results were obtained for ionic liquids, as well as some amphoteric and acidic NADES. In a two-cycle extraction process the best solvents were tested for the extraction of galanthamine from bulbs. The ionic liquids produced poor yields, and the best results were obtained with some acid and sugar mixtures, among which malic acid – sucrose – water (1:1:5) proved to be the best, showing similar yields to that of the exhaustive Soxhlet extraction with methanol. Furthermore, the NADES was more selective for galanthamine.
dc.description.sponsorshipThis research was funded by Directorate General for Higher Education (DGHE), Ministry of Education and Culture of The Republic of Indonesia via DIKTI PhD grant (Batch IV-2010) for O.R
dc.publisherGeorg Thieme Verlag KG
dc.relation.urlhttp://www.thieme-connect.de/DOI/DOI?10.1055/a-1803-3259
dc.rightsArchived with thanks to Planta Medica
dc.titlePressurized Natural Deep Eutectic Solvent Extraction of Galanthamine and related alkaloids from Narcissus pseudonarcissus
dc.typeArticle
dc.contributor.departmentBiology and Environmental Science and Engineering, King Abdullah University of Science and Technology (KAUST, Thuwal, Saudi Arabia
dc.contributor.departmentBiological and Environmental Science and Engineering (BESE) Division
dc.contributor.departmentEnvironmental Science and Engineering Program
dc.contributor.departmentWater Desalination and Reuse Research Center (WDRC)
dc.identifier.journalPlanta Medica
dc.rights.embargodate2023-03-18
dc.eprint.versionPost-print
dc.contributor.institutionChemical Engineering Department, Sepuluh Nopember Institute of Technology, Surabaya, Indonesia
dc.contributor.institutionIBL, Leiden University Faculty of Science, Leiden, Netherlands
dc.contributor.institutionCollege of Pharmacy, Kyung Hee University, Seoul, Republic of Korea, Seoul, Korea (the Republic of)
dc.contributor.institutionInstitute of Biology Leiden, University of Leiden, Leiden, Netherlands
kaust.personWitkamp, Geert Jan


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