Show simple item record

dc.contributor.authorChintawar, Chetan C.
dc.contributor.authorBhoyare, Vivek W.
dc.contributor.authorMane, Manoj Vasisht
dc.contributor.authorPatil, Nitin T.
dc.date.accessioned2022-04-20T06:06:48Z
dc.date.available2022-04-20T06:06:48Z
dc.date.issued2022-04-18
dc.identifier.citationChintawar, C. C., Bhoyare, V. W., Mane, M. V., & Patil, N. T. (2022). Enantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.2c02799
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.doi10.1021/jacs.2c02799
dc.identifier.urihttp://hdl.handle.net/10754/676330
dc.description.abstractPresented herein is the first report of enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos). The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans (up to 88% yield and 99% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C2-symmetric chiral environment present around nitrogen, imparting a high level of enantioselectivity
dc.description.sponsorshipGenerous financial support by the Science and Engineering Research Board (SERB), New Delhi (File Nos. DIA/2018/000016 and EMR/2016/007177), is gratefully acknowledged. C.C.C. and V.W.B. thank the UGC and CSIR, respectively, for the award of Senior Research Fellowships. We thank Abhik Paul from IISERB for his assistance with SC-XRD analysis.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/jacs.2c02799
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/jacs.2c02799.
dc.titleEnantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Centre, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.identifier.journalJournal of the American Chemical Society
dc.rights.embargodate2023-04-18
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Bhopal 462 066, India
dc.contributor.institutionPhysical Chemistry Division, CSIR−National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India
dc.contributor.institutionAcademy of Scientific and Innovative Research (AcSIR), New Delhi 110 025, India
kaust.personMane, Manoj Vasisht


This item appears in the following Collection(s)

Show simple item record