Metabolomic Study on Tridacna maxima Giant Clams Reveals Metabolic Fingerprint of Environmental Pollutants
Type
ArticleAuthors
Almulhim, Fatimah F.
Rossbach, Susann
Emwas, Abdul-Hamid M.
Kharbatia, Najeh M.
Jaremko, Lukasz

Jaremko, Mariusz

Duarte, Carlos M.

KAUST Department
Biological and Environmental Science and Engineering (BESE) DivisionBioscience
Bioscience Program
Computational Bioscience Research Center (CBRC)
CoreLabs, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia
Environmental Lab Organics & Inorganics
Marine Science Program
NMR
Red Sea Research Center (RSRC)
Water Desalination and Reuse Research Center (WDRC)
Date
2022-04-22Submitted Date
2021-11-11Permanent link to this record
http://hdl.handle.net/10754/675840
Metadata
Show full item recordAbstract
Metabolite profiling of marine invertebrates, such as bivalve mollusks, may not only provide insights into the health state of an individual holobiont, but also the pollution levels of their habitats. Here, we combined 1H nuclear magnetic responance (NMR) spectroscopy and mass spectrometry (MS)-based metabolomics techniques to investigate the tissue-specific metabolomic profiles of Tridacna maxima. Animals were collected from across across-shelf gradient in the Red Sea, from inshore to off-shore. We unequivocally profiled 306 metabolites and observed that the collection location had minimal effects on metabolite composition. However, we observed significant differences in metabolite profiles among different tissues (i.e., gills, mantle tissue, and digestive system). Importantly, in addition to endogenous metabolites, we detected the presence of terephthalic acid and isophthalic acid, which likely originate from marine plastic ingestion. Collectively, our study opens opportunities for a deeper understanding of Tridacna maxima physiology through metabolomics, and illustrates the power of invertebrate metabolite profiling for monitoring plastic-related aquatic pollutants.Citation
Almulhim, F., Rossbach, S., Emwas, A.-H., Kharbatia, N. M., Jaremko, L., Jaremko, M., & Duarte, C. M. (2022). Metabolomic Study on Tridacna maxima Giant Clams Reveals Metabolic Fingerprint of Environmental Pollutants. Frontiers in Marine Science, 9. https://doi.org/10.3389/fmars.2022.813404Sponsors
Authors want to acknowledge the funding support from the KAUST Smart Health Initiative (SHI) seed grants (LJ and MJ) and baseline funds (LJ, MJ, and CD)Publisher
Frontiersae974a485f413a2113503eed53cd6c53
10.3389/fmars.2022.813404
Scopus Count
Except where otherwise noted, this item's license is described as Archived with thanks to Accepted for publication in Frontiers in Marine Science under a Creative Commons license, details at: https://creativecommons.org/licenses/by/4.0/