Selective benzylic Csp3–H bond activations mediated by a phosphorus–nitrogen PN3P-nickel complex
Type
ArticleKAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
KAUST Catalysis Center and Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Date
2022Embargo End Date
2023-01-05Permanent link to this record
http://hdl.handle.net/10754/674872
Metadata
Show full item recordAbstract
In contrast to the typical Csp2−H activation, a PN3P-Nickel complex chemoselectively cleaved the benzylic Csp3–H bond of toluene in the presence of KHMDS, presumably via an in situ generated potassium benzyl intermediate. Under similar conditions, CO underwent deoxygenation to afford the corresponding nickel cyano complex, and ethylbenzene was dehydrogenated to give styrene and a nickel hydride compound. 2,6-xylyl isocyanide was transformed into an unprecedented indolyl complex, likely by trapping the activated benzyl species with a isocyanide moiety.Citation
Huang, K.-W., Yao, C., Zhang, T., & Goncalves, T. P. (2022). Selective benzylic Csp3–H bond activations mediated by a phosphorus–nitrogen PN3P-nickel complex. Chemical Communications. doi:10.1039/d1cc06507fPublisher
Royal Society of Chemistry (RSC)Journal
Chemical CommunicationsAdditional Links
http://pubs.rsc.org/en/Content/ArticleLanding/2022/CC/D1CC06507Fae974a485f413a2113503eed53cd6c53
10.1039/d1cc06507f