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    Effects of Pharmacotherapy, Neurodevelopment, Sex and Structural Asymmetry on Regional Intrinsic Homotopic Connectivity in Youths with Attention Deficit Hyperactivity Disorder.

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    [Final] Zainab_Homoud_Thesis_KAUST.pdf
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    Description:
    Zainab Homoud MS Thesis
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    Type
    Thesis
    Authors
    Homoud, Zainab cc
    Advisors
    Ombao, Hernando cc
    Committee members
    Hauser, Charlotte cc
    Al-Naffouri, Tareq Y. cc
    Program
    Bioengineering
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Date
    2021-12
    Permanent link to this record
    http://hdl.handle.net/10754/673897
    
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    Abstract
    Functional magnetic resonance imaging studies have long demonstrated a high degree of correlated activity between the left and right hemispheres of the brain. Interregional correlations between the time series of each brain voxel or region and its homotopic pair have recently been identified by methods such as homotopic resting-state functional connectivity (H-RSFC). However, little is known about whether interhemispheric regions in patients with Attention-deficit/hyperactivity disorder (ADHD) are functionally abnormal. The aim of this thesis is to examine the association between H-RSFC and medication status, age, sex, and volumetric asymmetry index (AI). In our approach, region-based activity was obtained using three different methods. To test for associations, two linear mixed-effects models were used. Across results, H-RSFC variation was found in subcortical regions and portions of cortical regions. In addition, changes in functional connectivity were found to be linked with structural asymmetry in two cortical regions. More importantly, shifting in homotopic functional activation was found as a result of medication intake in youths with ADHD. These findings demonstrate the utility of homotopic resting-state functional connectivity for measuring differences among pharmacotherapy intake, gender, neurodevelopment, and structural asymmetry.
    Citation
    Homoud, Z. (2021). Effects of Pharmacotherapy, Neurodevelopment, Sex and Structural Asymmetry on Regional Intrinsic Homotopic Connectivity in Youths with Attention Deficit Hyperactivity Disorder. KAUST Research Repository. https://doi.org/10.25781/KAUST-2X0AM
    DOI
    10.25781/KAUST-2X0AM
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-2X0AM
    Scopus Count
    Collections
    Bioengineering Program; Biological and Environmental Science and Engineering (BESE) Division; MS Theses

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