Electrophilic N-Trifluoromethylthiophthalimide as a Fluorinated Reagent in the Synthesis of Acyl Fluorides
KAUST DepartmentKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Chemical Science Program
Online Publication Date2021
Permanent link to this recordhttp://hdl.handle.net/10754/673844
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AbstractHerein we report the deoxygenated fluorination of readily available carboxylic acids. A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time. Scale-up reactions and sequential cross-couplings were performed successfully to demonstrate the practicability of this fluorination protocol.
CitationZhu, C., Zhumagazy, S., Yue, H., & Rueping, M. (2021). Electrophilic N-Trifluoromethylthiophthalimide as a Fluorinated Reagent in the Synthesis of Acyl Fluorides. Organic Chemistry Frontiers. doi:10.1039/d1qo01633d
PublisherRoyal Society of Chemistry (RSC)
JournalOrganic Chemistry Frontiers
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