Electrophilic N-Trifluoromethylthiophthalimide as a Fluorinated Reagent in the Synthesis of Acyl Fluorides

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Type
Article
Authors
Zhu, Chen cc
Zhumagazy, Serik cc
Yue, Huifeng
Rueping, Magnus cc
KAUST Department
KAUST Catalysis Center (KCC)
Chemical Science
Physical Science and Engineering (PSE) Division
Chemical Science Program
Date
2022
Online Publication Date
2021
Submitted Date
2021-11-02
Permanent link to this record
http://hdl.handle.net/10754/673844

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Abstract
Herein we report the deoxygenated fluorination of readily available carboxylic acids. A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time. Scale-up reactions and sequential cross-couplings were performed successfully to demonstrate the practicability of this fluorination protocol.
Citation
Zhu, C., Zhumagazy, S., Yue, H., & Rueping, M. (2021). Electrophilic N-Trifluoromethylthiophthalimide as a Fluorinated Reagent in the Synthesis of Acyl Fluorides. Organic Chemistry Frontiers. doi:10.1039/d1qo01633d
Publisher
Royal Society of Chemistry (RSC)
Journal
Organic Chemistry Frontiers
DOI
10.1039/d1qo01633d
Additional Links
http://pubs.rsc.org/en/Content/ArticleLanding/2021/QO/D1QO01633D
Collections
Articles; Physical Science and Engineering (PSE) Division; Chemical Science Program; KAUST Catalysis Center (KCC)
This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.