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dc.contributor.authorBettgenhaeuser, Jan
dc.contributor.authorHernández-Pinzón, Inmaculada
dc.contributor.authorDawson, Andrew M.
dc.contributor.authorGardiner, Matthew
dc.contributor.authorGreen, Phon
dc.contributor.authorTaylor, Jodie
dc.contributor.authorSmoker, Matthew
dc.contributor.authorFerguson, John N.
dc.contributor.authorEmmrich, Peter
dc.contributor.authorHubbard, Amelia
dc.contributor.authorBayles, Rosemary
dc.contributor.authorWaugh, Robbie
dc.contributor.authorSteffenson, Brian J.
dc.contributor.authorWulff, Brande B. H.
dc.contributor.authorDreiseitl, Antonín
dc.contributor.authorWard, Eric R.
dc.contributor.authorMoscou, Matthew J.
dc.date.accessioned2021-11-29T07:53:09Z
dc.date.available2021-11-29T07:53:09Z
dc.date.issued2021-11-25
dc.date.submitted2019-05-09
dc.identifier.citationBettgenhaeuser, J., Hernández-Pinzón, I., Dawson, A. M., Gardiner, M., Green, P., Taylor, J., … Moscou, M. J. (2021). The barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics. Nature Communications, 12(1). doi:10.1038/s41467-021-27288-3
dc.identifier.issn2041-1723
dc.identifier.doi10.1038/s41467-021-27288-3
dc.identifier.urihttp://hdl.handle.net/10754/673810
dc.description.abstractCrop losses caused by plant pathogens are a primary threat to stable food production. Stripe rust (Puccinia striiformis) is a fungal pathogen of cereal crops that causes significant, persistent yield loss. Stripe rust exhibits host species specificity, with lineages that have adapted to infect wheat and barley. While wheat stripe rust and barley stripe rust are commonly restricted to their corresponding hosts, the genes underlying this host specificity remain unknown. Here, we show that three resistance genes, Rps6, Rps7, and Rps8, contribute to immunity in barley to wheat stripe rust. Rps7 cosegregates with barley powdery mildew resistance at the Mla locus. Using transgenic complementation of different Mla alleles, we confirm allele-specific recognition of wheat stripe rust by Mla. Our results show that major resistance genes contribute to the host species specificity of wheat stripe rust on barley and that a shared genetic architecture underlies resistance to the adapted pathogen barley powdery mildew and non-adapted pathogen wheat stripe rust.
dc.description.sponsorshipThe authors greatly appreciated valuable discussions with Peter van Esse, Jonathan Jones, Sophien Kamoun, Nick Talbot, and Cyril Zipfel. Photography was supported by Andrew Davis and Phil Robinson. Assistance in the greenhouse was provided by Sue Banfield and the John Innes Horticultural team. Seed was kindly provided by Andy Kleinhofs, Rients Niks, Ralph Panstruga, Mapi Valles, Wolfgang Spielmeyer, Nils Stein, Wendy Harwood, Wheat Genetics Resource Center (Kansas State University), Patrick Hayes, Kazuhiro Sato, Roger Wise, and the National Small Grains Collection (USDA-ARS). Funding for this research includes Biotechnology and Biological Sciences Research Council Doctoral Training Programme (grant no. BB/F017294/1 to J.B. and M.J.M.) and Institute Strategic Programme (grant no. BB/J004553/1 to B.B.H.W., BB/P012574/1 to M.J.M., and BBS/E/J/000PR9795 to M.J.M.), Human Frontier Science Program Long-term Fellowship (grant no. LT000218/2011-L to M.J.M.), John Innes Foundation (rotation PhD studentship to PE), 2Blades Foundation, and Gatsby Charitable Foundation.
dc.publisherSpringer Science and Business Media LLC
dc.relation.urlhttps://www.nature.com/articles/s41467-021-27288-3
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleThe barley immune receptor Mla recognizes multiple pathogens and contributes to host range dynamics
dc.typeArticle
dc.contributor.departmentCenter for Desert Agriculture
dc.contributor.departmentCenter for Desert Agriculture, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.
dc.identifier.journalNature Communications
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionThe Sainsbury Laboratory, University of East Anglia, Norwich Research Park, Norwich, NR4 7UK, England, UK.
dc.identifier.volume12
dc.identifier.issue1
kaust.personWulff, Brande B. H.
dc.date.accepted2021-11-11
refterms.dateFOA2021-11-29T07:54:16Z
dc.date.published-online2021-11-25
dc.date.published-print2021-12


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This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder