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dc.contributor.authorSeferji, Kholoud
dc.contributor.authorSusapto, Hepi Hari
dc.contributor.authorKhan, Babar Khalid
dc.contributor.authorRehman, Zahid Ur
dc.contributor.authorAbbas, Manzar
dc.contributor.authorEmwas, Abdul-Hamid M.
dc.contributor.authorHauser, Charlotte
dc.date.accessioned2021-11-24T07:27:18Z
dc.date.available2021-11-24T07:27:18Z
dc.date.issued2021-11-23
dc.date.submitted2021-09-20
dc.identifier.citationSeferji, K. A., Susapto, H. H., Khan, B. K., Rehman, Z. U., Abbas, M., Emwas, A.-H., & Hauser, C. A. E. (2021). Green Synthesis of Silver-Peptide Nanoparticles Generated by the Photoionization Process for Anti-Biofilm Application. ACS Applied Bio Materials. doi:10.1021/acsabm.1c01013
dc.identifier.issn2576-6422
dc.identifier.issn2576-6422
dc.identifier.doi10.1021/acsabm.1c01013
dc.identifier.urihttp://hdl.handle.net/10754/673748
dc.description.abstractAn alarming increase in antibiotic-resistant bacterial strains is driving clinical demand for new antibacterial agents. One of the oldest antimicrobial agents is elementary silver (Ag), which has been used for thousands of years. Even today, elementary Ag is used for medical purposes such as treating burns, wounds, and microbial infections. In consideration of the effectiveness of elementary Ag, the present researchers generated effective antibacterial/antibiofilm agents by combining elementary Ag with biocompatible ultrashort peptide compounds. The innovative antibacterial agents comprised a hybrid peptide bound to Ag nanoparticles (IVFK/Ag NPs). These were generated by photoionizing a biocompatible ultrashort peptide, thus reducing Ag ions to form Ag NPs with a diameter of 6 nm. The IVFK/Ag NPs demonstrated promising antibacterial/antibiofilm activity against reference Gram-positive and Gram-negative bacteria compared with commercial Ag NPs. Through morphological changes in Escherichia coli and Staphylococcus aureus, we proposed that the mechanism of action for IVFK/Ag NPs derives from their ability to disrupt bacterial membranes. In terms of safety, the IVFK/Ag NPs demonstrated biocompatibility in the presence of human dermal fibroblast cells, and concentrations within the minimal inhibitory concentration had no significant effect on cell viability. These results demonstrated that hybrid peptide/Ag NPs hold promise as a biocompatible material with strong antibacterial/antibiofilm properties, allowing them to be applied across a wide range of applications in tissue engineering and regenerative medicine.
dc.description.sponsorshipThis work was supported by the King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. K.A.S. gratefully acknowledges the Taibah University (Saudi Arabia) for financial support.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acsabm.1c01013
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acsabm.1c01013.
dc.titleGreen Synthesis of Silver-Peptide Nanoparticles Generated by the Photoionization Process for Anti-Biofilm Application
dc.typeArticle
dc.contributor.departmentLaboratory for Nanomedicine, Division of Biological & Environmental Science & Engineering (BESE), King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
dc.contributor.departmentBioscience Program
dc.contributor.departmentBiological and Environmental Science and Engineering (BESE) Division
dc.contributor.departmentWater Desalination and Reuse Research Center (WDRC)
dc.contributor.departmentNMR
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalACS Applied Bio Materials
dc.rights.embargodate2022-11-23
dc.eprint.versionPost-print
dc.contributor.institutionBiology Department, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41411, Saudi Arabia
kaust.personSeferji, Kholoud A.
kaust.personSusapto, Hepi Hari
kaust.personKhan, Babar Khalid
kaust.personRehman, Zahid Ur
kaust.personAbbas, Manzar
kaust.personEmwas, Abdul-Hamid M.
kaust.personHauser, Charlotte
kaust.personHauser, Charlotte
dc.date.accepted2021-11-15


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