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    Green Synthesis of Silver-Peptide Nanoparticles Generated by the Photoionization Process for Anti-Biofilm Application

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    Name:
    Green Synthesis of Silver-Peptide Nanoparticles Generated by Photoionization Process for Anti-Biofilm Application.pdf
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    1.958Mb
    Format:
    PDF
    Description:
    Accepted Manuscript
    Embargo End Date:
    2022-11-23
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    Type
    Article
    Authors
    Seferji, Kholoud cc
    Susapto, Hepi Hari cc
    Khan, Babar Khalid cc
    Rehman, Zahid Ur cc
    Abbas, Manzar cc
    Emwas, Abdul-Hamid M.
    Hauser, Charlotte cc
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Bioscience Program
    Communication Theory Lab
    Computational Bioscience Research Center (CBRC)
    Extreme Systems Microbiology Lab
    Laboratory for Nanomedicine, Division of Biological & Environmental Science & Engineering (BESE), King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
    NMR
    Reef Ecology Lab
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2021-11-23
    Embargo End Date
    2022-11-23
    Submitted Date
    2021-09-20
    Permanent link to this record
    http://hdl.handle.net/10754/673748
    
    Metadata
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    Abstract
    An alarming increase in antibiotic-resistant bacterial strains is driving clinical demand for new antibacterial agents. One of the oldest antimicrobial agents is elementary silver (Ag), which has been used for thousands of years. Even today, elementary Ag is used for medical purposes such as treating burns, wounds, and microbial infections. In consideration of the effectiveness of elementary Ag, the present researchers generated effective antibacterial/antibiofilm agents by combining elementary Ag with biocompatible ultrashort peptide compounds. The innovative antibacterial agents comprised a hybrid peptide bound to Ag nanoparticles (IVFK/Ag NPs). These were generated by photoionizing a biocompatible ultrashort peptide, thus reducing Ag ions to form Ag NPs with a diameter of 6 nm. The IVFK/Ag NPs demonstrated promising antibacterial/antibiofilm activity against reference Gram-positive and Gram-negative bacteria compared with commercial Ag NPs. Through morphological changes in Escherichia coli and Staphylococcus aureus, we proposed that the mechanism of action for IVFK/Ag NPs derives from their ability to disrupt bacterial membranes. In terms of safety, the IVFK/Ag NPs demonstrated biocompatibility in the presence of human dermal fibroblast cells, and concentrations within the minimal inhibitory concentration had no significant effect on cell viability. These results demonstrated that hybrid peptide/Ag NPs hold promise as a biocompatible material with strong antibacterial/antibiofilm properties, allowing them to be applied across a wide range of applications in tissue engineering and regenerative medicine.
    Citation
    Seferji, K. A., Susapto, H. H., Khan, B. K., Rehman, Z. U., Abbas, M., Emwas, A.-H., & Hauser, C. A. E. (2021). Green Synthesis of Silver-Peptide Nanoparticles Generated by the Photoionization Process for Anti-Biofilm Application. ACS Applied Bio Materials. doi:10.1021/acsabm.1c01013
    Sponsors
    This work was supported by the King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia. K.A.S. gratefully acknowledges the Taibah University (Saudi Arabia) for financial support.
    Publisher
    American Chemical Society (ACS)
    Journal
    ACS Applied Bio Materials
    DOI
    10.1021/acsabm.1c01013
    Additional Links
    https://pubs.acs.org/doi/10.1021/acsabm.1c01013
    ae974a485f413a2113503eed53cd6c53
    10.1021/acsabm.1c01013
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Communication Theory Lab; Computational Bioscience Research Center (CBRC); Water Desalination and Reuse Research Center (WDRC)

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