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    Host-Directed editing of SARS-CoV-2 genome: From perspective of host APOBEC and ZAP

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    Type
    Poster
    Authors
    Sadykov, Mukhtar cc
    Mourier, Tobias cc
    Guan, Qingtian cc
    Pain, Arnab cc
    Date
    2021-11-22
    Permanent link to this record
    http://hdl.handle.net/10754/673418
    
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    Abstract
    RNA viruses use CpG reduction to evade the host cell defense, but the driving mechanism is still largely unknown. To address this, we used a rapidly growing genomic dataset of SARS-CoV-2 with relevant metadata information. Remarkably, by simply ordering SARS-CoV-2 genomes by their date of collection, we find a progressive increase of C-to-U substitutions resulting in CpG loss over just a few months. This is consistent with APOBEC-mediated RNA editing resulting in CpG reduction, thus allowing the virus to escape ZAP-mediated RNA degradation. Our results thus link the dynamics of target sequences in the viral genome for two known host molecular defense mechanisms, mediated by the APOBEC and ZAP proteins.
    Sponsors
    We thank all laboratories that have contributed sequences to the GISAID database and Zhadyra Yerkesh for giving her comments and helpful discussions. This work was supported by funding from KAUST R3T initiative.
    Conference/Event name
    KAUST R3T Week 2021
    Collections
    KAUST R3T Week 2021; Posters

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