Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis

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Type
Article
Authors
Guan, Qingtian cc
Alhuthali, Bushra
Mfarrej, Sara
Halim, Magid Abdel
Almaghrabi, Reem S
Pain, Arnab cc
KAUST Department
Biological and Environmental Science and Engineering (BESE) Division
Bioscience Program
Pathogen Genomics Laboratory
KAUST Grant Number
BAS/1/1020-01- 01
REI/1/4468-01-01]
Date
2021-11-05
Online Publication Date
2021-11-05
Print Publication Date
2022-07-14
Submitted Date
2021-08-09
Permanent link to this record
http://hdl.handle.net/10754/673327

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Abstract
We identified Naegleria fowleri as the aetiologic agent from cerebrospinal fluid (CSF) of a patient with a travel history to Karachi. We demonstrate the benefit of metagenomics-based rapid diagnosis of primary amoebic meningoencephalitis (PAM) when routine clinical tests fail to provide a definitive diagnosis. We reconstructed the N. fowleri genome.
Citation
Guan, Q., Alhuthali, B., Mfarrej, S., Halim, M. A., Almaghrabi, R. S., & Pain, A. (2021). Metagenomics-driven rapid diagnosis of an imported fatal case of rare amoebic meningoencephalitis. Journal of Travel Medicine. doi:10.1093/jtm/taab172
Sponsors
This work was supported by King Abdullah University of Science and Technology Smart Health Initiative fund [REI/1/4468-01-01] to A.P. and R.S.A. and a KAUST faculty baseline fund [BAS/1/1020-01- 01] AP.
Publisher
Oxford University Press (OUP)
Journal
Journal of Travel Medicine
DOI
10.1093/jtm/taab172
Additional Links
https://academic.oup.com/jtm/advance-article/doi/10.1093/jtm/taab172/6420899
Collections
Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License , which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License , which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.