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    Effect of Laminin derived IKVAV Motif and Ultrashort Self- Assembling Peptides on Cell Growth and Organoid Formation of Colorectal Cancer Stem Cells: Bioprintability Assessment

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    Fatimah Jalih Thesis.pdf
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    2.055Mb
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    Description:
    Fatimah Jalih Thesis
    Embargo End Date:
    2022-11-03
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    Type
    Thesis
    Authors
    Jalih, Fatimah
    Advisors
    Hauser, Charlotte cc
    Committee members
    Mahfouz, Magdy M. cc
    Gojobori, Takashi cc
    Program
    Bioscience
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Date
    2021-11
    Embargo End Date
    2022-11-03
    Permanent link to this record
    http://hdl.handle.net/10754/673183
    
    Metadata
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    Access Restrictions
    At the time of archiving, the student author of this thesis opted to temporarily restrict access to it. The full text of this thesis will become available to the public after the expiration of the embargo on 2022-11-03.
    Abstract
    Over the past decades, many studies have been conducted to generate in vitro tissue systems that help understanding tissue development and disease progression. Hydrogel scaffolds have been frequently used in creating such models. Self-assembling peptide hydrogels are functional in providing the cells a scaffold that supports cell proliferation, however, organoid and lumen formation remains a challenge. Hydrogels can be synthesized and modified based on the essential physiological properties, which can be achieved by altering the chemical composition of the initial material. Thus, in this study, we test the effect of the laminin-derived IKVAV motif on ultrashort self-assembling peptide in relation to cell proliferation and lumen formation in colorectal cancer stem cells. Further, we test the printability of the modified peptide. The modification of ultrashort peptide serves the purpose of providing signals to direct cell adhesion, differentiation, and lumen formation. One particular combination of peptides showed the formation of colorectal organoids containing lumen of outperforming characteristics as compared to the others, also in 3D bioprinting.
    Citation
    Jalih, F. (2021). Effect of Laminin derived IKVAV Motif and Ultrashort Self- Assembling Peptides on Cell Growth and Organoid Formation of Colorectal Cancer Stem Cells: Bioprintability Assessment. KAUST Research Repository. https://doi.org/10.25781/KAUST-Y1C8N
    DOI
    10.25781/KAUST-Y1C8N
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-Y1C8N
    Scopus Count
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; MS Theses

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