RNA editing differently affects protein-coding genes in D. melanogaster and H. sapiens
KAUST Grant NumberKUK-I1-012-43
Permanent link to this recordhttp://hdl.handle.net/10754/673035
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AbstractWhen an RNA editing event occurs within a coding sequence it can lead to a different encoded amino acid. The biological significance of these events remains an open question: they can modulate protein functionality, increase the complexity of transcriptomes or arise from a loose specificity of the involved enzymes. We analysed the editing events in coding regions that produce or not a change in the encoded amino acid (nonsynonymous and synonymous events, respectively) in D. melanogaster and in H. sapiens and compared them with the appropriate random models. Interestingly, our results show that the phenomenon has rather different characteristics in the two organisms. For example, we confirm the observation that editing events occur more frequently in non-coding than in coding regions, and report that this effect is much more evident in H. sapiens. Additionally, in this latter organism, editing events tend to affect less conserved residues. The less frequently occurring editing events in Drosophila tend to avoid drastic amino acid changes. Interestingly, we find that, in Drosophila, changes from less frequently used codons to more frequently used ones are favoured, while this is not the case in H. sapiens.
CitationGrassi, L., Leoni, G., & Tramontano, A. (2015). RNA editing differently affects protein-coding genes in D. melanogaster and H. sapiens. Scientific Reports, 5(1). doi:10.1038/srep11550
SponsorsAll the authors are very grateful to Marco Cosentino Lagomarsino for useful discussions. The support by KAUST Award KUK-I1-012-43, PRIN 20108XYHJS and the Epigenomics flagship project EPIGEN is gratefully acknowledged.
PubMed Central IDPMC4648400
CollectionsPublications Acknowledging KAUST Support
- Complete sequence of the maize chloroplast genome: gene content, hotspots of divergence and fine tuning of genetic information by transcript editing.
- Authors: Maier RM, Neckermann K, Igloi GL, Kössel H
- Issue date: 1995 Sep 1
- The evolution of small insertions and deletions in the coding genes of Drosophila melanogaster.
- Authors: Chong Z, Zhai W, Li C, Gao M, Gong Q, Ruan J, Li J, Jiang L, Lv X, Hungate E, Wu CI
- Issue date: 2013 Dec
- RNA editing sites exist in protein-coding genes in the chloroplast genome of Cycas taitungensis.
- Authors: Chen H, Deng L, Jiang Y, Lu P, Yu J
- Issue date: 2011 Dec
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- Authors: Jin Y, Tian N, Cao J, Liang J, Yang Z, Lv J
- Issue date: 2007 Jun 27
- Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing.
- Authors: Mazloomian A, Meyer IM
- Issue date: 2015