RNA editing differently affects protein-coding genes in D. melanogaster and H. sapiens
Type
ArticleKAUST Grant Number
KUK-I1-012-43Date
2015Permanent link to this record
http://hdl.handle.net/10754/673034
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When an RNA editing event occurs within a coding sequence it can lead to a different encoded amino acid. The biological significance of these events remains an open question: they can modulate protein functionality, increase the complexity of transcriptomes or arise from a loose specificity of the involved enzymes. We analysed the editing events in coding regions that produce or not a change in the encoded amino acid (nonsynonymous and synonymous events, respectively) in D. melanogaster and in H. sapiens and compared them with the appropriate random models. Interestingly, our results show that the phenomenon has rather different characteristics in the two organisms. For example, we confirm the observation that editing events occur more frequently in non-coding than in coding regions, and report that this effect is much more evident in H. sapiens. Additionally, in this latter organism, editing events tend to affect less conserved residues. The less frequently occurring editing events in Drosophila tend to avoid drastic amino acid changes. Interestingly, we find that, in Drosophila, changes from less frequently used codons to more frequently used ones are favoured, while this is not the case in H. sapiens.Citation
Grassi, L., Leoni, G., & Tramontano, A. (2015). RNA editing differently affects protein-coding genes in D. melanogaster and H. sapiens. Scientific Reports, 5(1). doi:10.1038/srep11550Sponsors
All the authors are very grateful to Marco Cosentino Lagomarsino for useful discussions. The support by KAUST Award KUK-I1-012-43, PRIN 20108XYHJS and the Epigenomics flagship project EPIGEN is gratefully acknowledged.Publisher
NATURE PORTFOLIOJournal
SCIENTIFIC REPORTSPubMed ID
26169954PubMed Central ID
PMC4648400Additional Links
http://www.nature.com/articles/srep11550ae974a485f413a2113503eed53cd6c53
10.1038/srep11550
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