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dc.contributor.authorAguilar-Arnal, Lorena
dc.contributor.authorSassone-Corsi, Paolo
dc.date.accessioned2021-10-31T12:47:05Z
dc.date.available2021-10-31T12:47:05Z
dc.date.issued2015
dc.identifier.citationAguilar-Arnal, L., & Sassone-Corsi, P. (2014). Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription. Proceedings of the National Academy of Sciences, 112(22), 6863–6870. doi:10.1073/pnas.1411264111
dc.identifier.issn0027-8424
dc.identifier.doi10.1073/pnas.1411264111
dc.identifier.urihttp://hdl.handle.net/10754/673013
dc.description.abstractCircadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in ∼24-h cycles. This control is achieved through a complex program of gene expression. In mammals, the molecular clock machinery consists of interconnected transcriptional–translational feedback loops that ultimately ensure the proper oscillation of thousands of genes in a tissue-specific manner. To achieve circadian transcriptional control, chromatin remodelers serve the clock machinery by providing appropriate oscillations to the epigenome. Recent findings have revealed the presence of circadian interactomes, nuclear “hubs” of genome topology where coordinately expressed circadian genes physically interact in a spatial and temporal-specific manner. Thus, a circadian nuclear landscape seems to exist, whose interplay with metabolic pathways and clock regulators translates into specific transcriptional programs. Deciphering the molecular mechanisms that connect the circadian clock machinery with the nuclear landscape will reveal yet unexplored pathways that link cellular metabolism to epigenetic control.
dc.description.sponsorshipWe thank all the members of the P.S.-C. laboratory for discussions and insights. Work in the Center for Epigenetics and Metabolism is supported by the National Institutes of Health, Merieux Research Grants, King Abdullah University of Science and Technology, and INSERM. L.A.-A. is supported in part by a European Molecular Biology Organization long-term fellowship.
dc.publisherNATL ACAD SCIENCES
dc.relation.urlhttp://www.pnas.org/lookup/doi/10.1073/pnas.1411264111
dc.subjectcircadian rhythms
dc.subjectchromatin
dc.subjectepigenetics
dc.subjectnuclear organization
dc.titleChromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription
dc.typeArticle
dc.identifier.journalProceedings of the National Academy of Sciences
dc.identifier.wosutWOS:000355832200042
dc.contributor.institutionUniv Calif Irvine, Dept Biol Chem, INSERM, Ctr Epigenet & Metab,U904, Irvine, CA 92697 USA
dc.identifier.volume112
dc.identifier.issue22
dc.identifier.pages6863-6870
dc.identifier.eid2-s2.0-84930629281


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