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    Untargeted metabolic profiling of extracellular vesicles of sars-cov-2-infected patients shows presence of potent anti-inflammatory metabolites

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    Type
    Article
    Authors
    Alzahrani, Faisal A. cc
    Mohammed, Mohammed Razeeth Shait cc
    Alkarim, Saleh
    Azhar, Esam I. cc
    El-Magd, Mohammed A. cc
    Hawsawi, Yousef cc
    Abdulaal, Wesam H. cc
    Yusuf, Abdulaziz cc
    Alhatmi, Abdulaziz
    Albiheyri, Raed cc
    Fakhurji, Burhan
    Kurdi, Bassem cc
    Madani, Tariq A.
    Alguridi, Hassan
    Alosaimi, Roaa S. cc
    Khan, Mohammad Imran cc
    Date
    2021-09-28
    Permanent link to this record
    http://hdl.handle.net/10754/672165
    
    Metadata
    Show full item record
    Abstract
    Extracellular vesicles (EVs) carry important biomolecules, including metabolites, and contribute to the spread and pathogenesis of some viruses. However, to date, limited data are available on EV metabolite content that might play a crucial role during infection with the SARS-CoV-2 virus. Therefore, this study aimed to perform untargeted metabolomics to identify key metabolites and associated pathways that are present in EVs, isolated from the serum of COVID-19 patients. The results showed the presence of antivirals and antibiotics such as Foscarnet, Indinavir, and lymecycline in EVs from patients treated with these drugs. Moreover, increased levels of anti-inflammatory metabolites such as LysoPS, 7-α,25-Dihydroxycholesterol, and 15-d-PGJ2 were detected in EVs from COVID-19 patients when compared with controls. Further, we found decreased levels of metabolites associated with coagulation, such as thromboxane and elaidic acid, in EVs from COVID-19 patients. These findings suggest that EVs not only carry active drug molecules but also anti-inflammatory metabolites, clearly suggesting that exosomes might play a crucial role in negotiating with heightened inflammation during COVID-19 infection. These preliminary results could also pave the way for the identification of novel metabolites that might act as critical regulators of inflammatory pathways during viral infections.
    Citation
    Alzahrani, F. A., Shait Mohammed, M. R., Alkarim, S., Azhar, E. I., El-Magd, M. A., Hawsawi, Y., … Khan, M. I. (2021). Untargeted Metabolic Profiling of Extracellular Vesicles of SARS-CoV-2-Infected Patients Shows Presence of Potent Anti-Inflammatory Metabolites. International Journal of Molecular Sciences, 22(19), 10467. doi:10.3390/ijms221910467
    Sponsors
    The authors acknowledge the financial support provided by King Abdulaziz City for Science and Technology (General Directorate for Research & Innovation Support) (GDRIS) (King Abdulaziz University). This work was conducted through the fasttrack program for COVID-19 Research, Project No. 0067-009-01-20-5. We extend our sincere thanks to both the Infectious Diseases Departments, King Abdulaziz University Hospital and East Jeddah Hospital, for their assistance in collecting patient samples. We extend our gratitude to the Core Metabolomics Facility, Department of Biochemistry, Faculty of Science, KAU, and the Central Laboratory of King Abdullah University of Science and Technology. We also extend our sincere thanks to the Immunology unit at the King Fahd Center for Medical Research. Additionally, we would like to thank King Faisal Specialist Hospital and Research Center, Jeddah, for their technical support (IRB approval No: 2020-47). Thanks are also extended to Moulay Mohammed, Faris Arar, Fadwa Al-Otaibi, Noor Bin Zaqer, and Eman Alghmadi for their assistance. Finally, a special thanks goes to the project consultant, Kenneth Witwer.
    Publisher
    MDPI AG
    Journal
    International Journal of Molecular Sciences
    DOI
    10.3390/ijms221910467
    Additional Links
    https://www.mdpi.com/1422-0067/22/19/10467
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms221910467
    Scopus Count
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