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dc.contributor.authorKoreny, Ludek
dc.contributor.authorSobotka, Roman
dc.contributor.authorJanouskovec, Jan
dc.contributor.authorKeeling, Patrick J.
dc.contributor.authorObornik, Miroslav
dc.date.accessioned2021-09-15T12:45:51Z
dc.date.available2021-09-15T12:45:51Z
dc.date.issued2011
dc.identifier.citationKořený, L., Sobotka, R., Janouškovec, J., Keeling, P. J., & Oborník, M. (2011). Tetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites  . The Plant Cell, 23(9), 3454–3462. doi:10.1105/tpc.111.089102
dc.identifier.issn1531-298X
dc.identifier.issn1040-4651
dc.identifier.doi10.1105/tpc.111.089102
dc.identifier.urihttp://hdl.handle.net/10754/671254
dc.description.abstractMost photosynthetic eukaryotes synthesize both heme and chlorophyll via a common tetrapyrrole biosynthetic pathway starting from glutamate. This pathway was derived mainly from cyanobacterial predecessor of the plastid and differs from the heme synthesis of the plastid-lacking eukaryotes. Here, we show that the coral-associated alveolate Chromera velia, the closest known photosynthetic relative to Apicomplexa, possesses a tetrapyrrole pathway that is homologous to the unusual pathway of apicomplexan parasites. We also demonstrate that, unlike other eukaryotic phototrophs, Chromera synthesizes chlorophyll from glycine and succinyl-CoA rather than glutamate. Our data shed light on the evolution of the heme biosynthesis in parasitic Apicomplexa and photosynthesis-related biochemical processes in their ancestors.
dc.description.sponsorshipThis work was supported by the Czech Science Foundation (GA206/08/1423), the Grant Agency of the Academy of Sciences of the Czech Republic (IAA601410907), by Award IC/2010/09 made by King Abdullah University of Science and Technology, by the project Algatech (CZ.1.05/2.1.00/03.0110), and by the Grant Agency of University of South Bohemia (GAJU 146/2010/P) to M.O.; by Institutional Research Concept AV0Z50200510 to R.S.; and by the Canadian Institutes for Health Research (MOP42517) to P.J.K. P.J.K. is a Fellow of the Canadian Institute for Advanced Research and a Senior Scholar of the Michael Smith Foundation for Health Research.
dc.publisherOxford University Press (OUP)
dc.relation.urlhttps://academic.oup.com/plcell/article/23/9/3454/6097679
dc.rightsThis is a pre-copyedited, author-produced PDF of an article accepted for publication in PLANT CELL following peer review. The version of record is available online at: https://academic.oup.com/plcell/article/23/9/3454/6097679.
dc.titleTetrapyrrole Synthesis of Photosynthetic Chromerids Is Likely Homologous to the Unusual Pathway of Apicomplexan Parasites
dc.typeArticle
dc.identifier.journalThe Plant Cell
dc.identifier.wosutWOS:000296739100030
dc.eprint.versionPost-print
dc.contributor.institutionInstitute of Parasitology, Biology Centre, Academy of Sciences of the Czech Republic, and Faculty of Science, University of South Bohemia, Branišovská 31, 37005 České Budějovice, Czech Republic
dc.contributor.institutionInstitute of Microbiology, Academy of Sciences of the Czech Republic, 37981 Třeboň, Czech Republic
dc.contributor.institutionDepartment of Botany, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
dc.identifier.volume23
dc.identifier.issue9
dc.identifier.pages3454-3462
kaust.grant.numberIC/2010/09
dc.identifier.eid2-s2.0-80055012864


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