The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptions to host-switching
de Alvarenga, Denise Anete Madureira
de Pina-Costa, Anielle
Guzmán-Vega, Francisco J.
de Abreu, Filipe Vieira Santos
Júnior, Cesare Bianco
Junior, Julio Cesar de Souza
Moreira, Silvia Bahadian
Hirano, Zelinda Maria Braga
Ferreira-da-Cruz, Maria de Fátima
de Oliveira, Ricardo Lourenço
Arold, Stefan T.
Jeffares, Daniel C.
de Brito, Cristiana Ferreira Alves
Daniel-Ribeiro, Cláudio Tadeu
Biological and Environmental Science and Engineering (BESE) Division
Computational Bioscience Research Center (CBRC)
Pathogen Genomics Laboratory
Structural Biology and Engineering
Permanent link to this recordhttp://hdl.handle.net/10754/671183
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AbstractPlasmodium simium, a parasite of various species of Platyrrhini monkeys whose range is restricted to the Atlantic Forest of Brazil, is genetically and morphologically similar to P. vivax. Based on this similarity, it appears likely that P. simium originated as a parasite of monkeys in Brazil following a host switch from humans carrying P. vivax. The 2015 outbreak of P. simium in the local human population raised questions about the degree of divergence that has occurred between P. vivax and P. simium, and whether adaptation to monkeys has led to the evolution of a parasite with clinical relevance to human health that differs from that of P. vivax. The degree and nature of adaptation to a non-human primate host and a sylvatic transmission cycle that has occurred in P. simium following its anthroponotic origin is of relevance to the understanding of how malaria parasites adapt to new hosts. It is also of interest to determine whether the current, human-infecting P. simium parasites have recently undergone changes at the genomic level that have allowed them to infect people in this region, as it has previously been suggested that P. simium has historically lacked the ability to infect man.
RelationsIs Supplement To:
Mourier, T., de Alvarenga, D. A. M., Kaushik, A., de Pina-Costa, A., Douvropoulou, O., Guan, Q., … Pain, A. (2019). The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host-switching. doi:10.1101/841171. DOI: 10.1101/841171 Handle: 10754/664279
Mourier, T., de Alvarenga, D. A. M., Kaushik, A., de Pina-Costa, A., Douvropoulou, O., Guan, Q., … Pain, A. (2021). The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching. BMC Biology, 19(1). doi:10.1186/s12915-021-01139-5. DOI: 10.1186/s12915-021-01139-5 Handle: 10754/664279