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dc.contributor.authorMuralirajan, Krishnamoorthy
dc.contributor.authorKancherla, Rajesh
dc.contributor.authorGimnkhan, Aidana
dc.contributor.authorRueping, Magnus
dc.date.accessioned2021-08-30T12:24:28Z
dc.date.available2021-08-30T12:24:28Z
dc.date.issued2021-08-25
dc.identifier.citationMuralirajan, K., Kancherla, R., Gimnkhan, A., & Rueping, M. (2021). Unactivated Alkyl Chloride Reactivity in Excited-State Palladium Catalysis. Organic Letters. doi:10.1021/acs.orglett.1c02467
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.pmid34432470
dc.identifier.doi10.1021/acs.orglett.1c02467
dc.identifier.urihttp://hdl.handle.net/10754/670850
dc.description.abstractExcited-state palladium catalysis is an efficient process for the alkylation of diverse organic compounds via the generation of alkyl radicals from alkyl bromides and iodides. However, the generation of alkyl radicals from more stable alkyl chlorides remains challenging. Herein, we demonstrate the excited-state palladium-catalyzed synthesis of oxindoles and isoquinolinediones via alkylation/annulation reaction by overcoming inherent limitations associated with unactivated C(sp<sup>3</sup>)-Cl bond activation at room temperature.
dc.description.sponsorshipWe acknowledge King Abdullah University of Science and Technology (KAUST) for support. This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/4025).
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/acs.orglett.1c02467
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.orglett.1c02467.
dc.titleUnactivated Alkyl Chloride Reactivity in Excited-State Palladium Catalysis
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentChemical Science Program
dc.identifier.journalOrganic Letters
dc.rights.embargodate2022-08-25
dc.eprint.versionPost-print
kaust.personMuralirajan, Krishnamoorthy
kaust.personKancherla, Rajesh
kaust.personGimnkhan, Aidana
kaust.personRueping, Magnus
kaust.grant.numberURF/1/4025
refterms.dateFOA2021-08-31T05:37:23Z
kaust.acknowledged.supportUnitOffice of Sponsored Research
dc.date.published-online2021-08-25
dc.date.published-print2021-09-03


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