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dc.contributor.authorVeloz Castillo, Maria Fernanda
dc.contributor.authorMagistretti, Pierre J.
dc.contributor.authorCali, Corrado
dc.date.accessioned2021-08-29T13:27:33Z
dc.date.available2021-08-29T13:27:33Z
dc.date.issued2021-08-20
dc.date.submitted2021-07-14
dc.identifier.citationVeloz Castillo, M. F., Magistretti, P. J., & Calì, C. (2021). l-Lactate: Food for Thoughts, Memory and Behavior. Metabolites, 11(8), 548. doi:10.3390/metabo11080548
dc.identifier.issn2218-1989
dc.identifier.pmid34436491
dc.identifier.doi10.3390/metabo11080548
dc.identifier.urihttp://hdl.handle.net/10754/670814
dc.description.abstractMore and more evidence shows how brain energy metabolism is the linkage between physiological and morphological synaptic plasticity and memory consolidation. Different types of memory are associated with differential inputs, each with specific inputs that are upstream diverse molecular cascades depending on the receptor activity. No matter how heterogeneous the response is, energy availability represents the lowest common denominator since all these mechanisms are energy consuming and the brain networks adapt their performance accordingly. Astrocytes exert a primary role in this sense by acting as an energy buffer; glycogen granules, a mechanism to store glucose, are redistributed at glance and conveyed to neurons via the Astrocyte-Neuron Lactate Shuttle (ANLS). Here, we review how different types of memory relate to the mechanisms of energy delivery in the brain.
dc.description.sponsorshipWe thank Matthew Fechtmeyer (English Language and Communication Program, KAUST) for critical review and grammatical editing of the manuscript.
dc.description.sponsorshipThis research was funded by KAUST baseline to P.J.M.
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/2218-1989/11/8/548
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectMetabolism
dc.subjectGlycogen
dc.subjectLearning
dc.subjectBehavior
dc.subjectLactate
dc.titlel-Lactate: Food for Thoughts, Memory and Behavior.
dc.typeArticle
dc.contributor.departmentBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
dc.contributor.departmentBioscience Program
dc.contributor.departmentBiological and Environmental Science and Engineering (BESE) Division
dc.contributor.departmentOffice of the President
dc.identifier.journalMetabolites
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDipartimento di Neuroscienze “Rita Levi Montalcini”, Università degli Studi di Torino, 10124 Torino, Italy.
dc.contributor.institutionNeuroscience Institute Cavalieri Ottolenghi, 10043 Orbassano, Italy.
dc.identifier.volume11
dc.identifier.issue8
dc.identifier.pages548
kaust.personVeloz Castillo, María Fernanda
kaust.personMagistretti, Pierre J.
dc.date.accepted2021-08-11
refterms.dateFOA2021-08-29T13:28:33Z


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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.