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dc.contributor.authorSantoro, Erika P.
dc.contributor.authorBorges, Ricardo M.
dc.contributor.authorEspinoza, Josh L.
dc.contributor.authorFreire, Marcelo
dc.contributor.authorMessias, Camila S. M. A.
dc.contributor.authorVillela, Helena D. M.
dc.contributor.authorPereira, Leandro M.
dc.contributor.authorVilela, Caren L. S.
dc.contributor.authorRosado, João G.
dc.contributor.authorCardoso, Pedro M.
dc.contributor.authorRosado, Phillipe M.
dc.contributor.authorAssis, Juliana M.
dc.contributor.authorDuarte, Gustavo A. S.
dc.contributor.authorPerna, Gabriela
dc.contributor.authorRosado, Alexandre S.
dc.contributor.authorMacrae, Andrew
dc.contributor.authorDupont, Christopher L.
dc.contributor.authorNelson, Karen E.
dc.contributor.authorSweet, Michael
dc.contributor.authorVoolstra, Christian R.
dc.contributor.authorPeixoto, Raquel S
dc.date.accessioned2021-08-15T07:24:08Z
dc.date.available2021-08-15T07:24:08Z
dc.date.issued2021-08-13
dc.date.submitted2020-12-23
dc.identifier.citationSantoro, E. P., Borges, R. M., Espinoza, J. L., Freire, M., Messias, C. S. M. A., Villela, H. D. M., … Peixoto, R. S. (2021). Coral microbiome manipulation elicits metabolic and genetic restructuring to mitigate heat stress and evade mortality. Science Advances, 7(33), eabg3088. doi:10.1126/sciadv.abg3088
dc.identifier.issn2375-2548
dc.identifier.doi10.1126/sciadv.abg3088
dc.identifier.urihttp://hdl.handle.net/10754/670602
dc.description.abstractBeneficial microorganisms for corals (BMCs) ameliorate environmental stress, but whether they can prevent mortality and the underlying host response mechanisms remains elusive. Here, we conducted omics analyses on the coral Mussismilia hispida exposed to bleaching conditions in a long-term mesocosm experiment and inoculated with a selected BMC consortium or a saline solution placebo. All corals were affected by heat stress, but the observed “post-heat stress disorder” was mitigated by BMCs, signified by patterns of dimethylsulfoniopropionate degradation, lipid maintenance, and coral host transcriptional reprogramming of cellular restructuration, repair, stress protection, and immune genes, concomitant with a 40% survival rate increase and stable photosynthetic performance by the endosymbiotic algae. This study provides insights into the responses that underlie probiotic host manipulation. We demonstrate that BMCs trigger a dynamic microbiome restructuring process that instigates genetic and metabolic alterations in the coral host that eventually mitigate coral bleaching and mortality.
dc.description.sponsorshipThis research project won the Great Barrier Reef Foundation’s Out of the Blue Box Reef Innovation Challenge People’s Choice Award supported by The Tiffany & Co.Foundation. C.R.V. was supported through the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) Project Numbers 433042944 and 458901010. R.S.P. was supported through KAUST grant number BAS/1/1095-01-01 and the Rio de Janeiro Marine Aquarium Research Center. E.P.S. received support from the Graduate Programs of Science (Microbiology) and Plant Biotechnology and Bioprocess Engineering (PBV)/Federal University of Rio de Janeiro, the Brazilian Government Research Agency CAPES, and the CAPES PRINT international mobility grant.
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.relation.urlhttps://advances.sciencemag.org/lookup/doi/10.1126/sciadv.abg3088
dc.rightsExclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleCoral microbiome manipulation elicits metabolic and genetic restructuring to mitigate heat stress and evade mortality
dc.typeArticle
dc.contributor.departmentRed Sea Research Center (RSRC), Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
dc.contributor.departmentMarine Science Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentDivision of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.identifier.journalScience Advances
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstitute of Microbiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
dc.contributor.institutionWalter Mors Institute of Research on Natural Products, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
dc.contributor.institutionDepartment of Genomic Medicine and Infectious Diseases, J. Craig Venter Institute, La Jolla, CA, USA.
dc.contributor.institutionApplied Sciences, Durban University of Technology, Durban, South Africa.
dc.contributor.institutionDepartment of Infectious Diseases and Global Health, School of Medicine, University of California San Diego, La Jolla, CA, USA.
dc.contributor.institutionDepartment of Biology, University of Konstanz, Konstanz 78457, Germany.
dc.contributor.institutionAquatic Research Facility, Environmental Sustainability Research Centre, University of Derby, Derby, UK.
dc.identifier.volume7
dc.identifier.issue33
dc.identifier.pageseabg3088
kaust.personRosado, João G.
kaust.personPerna, Gabriela
kaust.personRosado, Alexandre S.
kaust.personVoolstra, Christian R.
kaust.personPeixoto, Raquel S.
kaust.grant.numberBAS/1/1095-01-01
dc.date.accepted2021-06-24
refterms.dateFOA2021-08-15T07:28:16Z
kaust.acknowledged.supportUnitBAS
dc.date.published-online2021-08-13
dc.date.published-print2021-08


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Exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Except where otherwise noted, this item's license is described as Exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).