Coral microbiome manipulation elicits metabolic and genetic restructuring to mitigate heat stress and evade mortality
AuthorsSantoro, Erika P.
Borges, Ricardo M.
Espinoza, Josh L.
Messias, Camila S. M. A.
Villela, Helena D. M.
Pereira, Leandro M.
Vilela, Caren L. S.
Rosado, João G.
Cardoso, Pedro M.
Rosado, Phillipe M.
Assis, Juliana M.
Duarte, Gustavo A. S.
Rosado, Alexandre S.
Dupont, Christopher L.
Nelson, Karen E.
Voolstra, Christian R.
Peixoto, Raquel S
KAUST DepartmentRed Sea Research Center (RSRC), Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Marine Science Program
Biological and Environmental Sciences and Engineering (BESE) Division
Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
Red Sea Research Center (RSRC)
KAUST Grant NumberBAS/1/1095-01-01
Permanent link to this recordhttp://hdl.handle.net/10754/670602
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AbstractBeneficial microorganisms for corals (BMCs) ameliorate environmental stress, but whether they can prevent mortality and the underlying host response mechanisms remains elusive. Here, we conducted omics analyses on the coral Mussismilia hispida exposed to bleaching conditions in a long-term mesocosm experiment and inoculated with a selected BMC consortium or a saline solution placebo. All corals were affected by heat stress, but the observed “post-heat stress disorder” was mitigated by BMCs, signified by patterns of dimethylsulfoniopropionate degradation, lipid maintenance, and coral host transcriptional reprogramming of cellular restructuration, repair, stress protection, and immune genes, concomitant with a 40% survival rate increase and stable photosynthetic performance by the endosymbiotic algae. This study provides insights into the responses that underlie probiotic host manipulation. We demonstrate that BMCs trigger a dynamic microbiome restructuring process that instigates genetic and metabolic alterations in the coral host that eventually mitigate coral bleaching and mortality.
CitationSantoro, E. P., Borges, R. M., Espinoza, J. L., Freire, M., Messias, C. S. M. A., Villela, H. D. M., … Peixoto, R. S. (2021). Coral microbiome manipulation elicits metabolic and genetic restructuring to mitigate heat stress and evade mortality. Science Advances, 7(33), eabg3088. doi:10.1126/sciadv.abg3088
SponsorsThis research project won the Great Barrier Reef Foundation’s Out of the Blue Box Reef Innovation Challenge People’s Choice Award supported by The Tiffany & Co.Foundation. C.R.V. was supported through the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) Project Numbers 433042944 and 458901010. R.S.P. was supported through KAUST grant number BAS/1/1095-01-01 and the Rio de Janeiro Marine Aquarium Research Center. E.P.S. received support from the Graduate Programs of Science (Microbiology) and Plant Biotechnology and Bioprocess Engineering (PBV)/Federal University of Rio de Janeiro, the Brazilian Government Research Agency CAPES, and the CAPES PRINT international mobility grant.
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