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dc.contributor.authorAbdelrahman, Sherin
dc.contributor.authorAlghrably, Mawadda
dc.contributor.authorCampagna, Marcello
dc.contributor.authorHauser, Charlotte
dc.contributor.authorJaremko, Mariusz
dc.contributor.authorLachowicz, Joanna Izabela
dc.date.accessioned2021-08-08T08:15:20Z
dc.date.available2021-08-08T08:15:20Z
dc.date.issued2021-08-05
dc.date.submitted2021-07-09
dc.identifier.citationAbdelrahman, S., Alghrably, M., Campagna, M., Hauser, C. A. E., Jaremko, M., & Lachowicz, J. I. (2021). Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin. Molecules, 26(16), 4730. doi:10.3390/molecules26164730
dc.identifier.issn1420-3049
dc.identifier.doi10.3390/molecules26164730
dc.identifier.urihttp://hdl.handle.net/10754/670468
dc.description.abstractMetformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects. Diabetes is a significant cancer risk factor, but unexpectedly, metformin-treated diabetic patients have lower cancer incidence. Here, we show that metformin forms stable complexes with copper (II) ions. Both copper(I)/metformin and copper(II)/metformin complexes form adducts with glutathione, the main intracellular antioxidative peptide, found at high levels in cancer cells. Metformin reduces cell number and viability in SW1222 and K562 cells, as well as in K562-200 multidrug-resistant cells. Notably, the antiproliferative effect of metformin is enhanced in the presence of copper ions.
dc.description.sponsorshipWe would like to thank Farid Ahmad from the center of excellence in genomic medicine research (CEGMR) for providing both the K562 and K562/Adr200 cell lines.
dc.publisherMDPI AG
dc.relation.urlhttps://www.mdpi.com/1420-3049/26/16/4730
dc.rightsThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleMetal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin
dc.typeArticle
dc.contributor.departmentBiological and Environmental Science and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentEnvironmental Science and Engineering Program
dc.contributor.departmentLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
dc.identifier.journalMolecules
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Medical Sciences and Public Health, University of Cagliari, Policlinico Universitario, 09124 Cagliari, Italy.
dc.identifier.volume26
dc.identifier.issue16
dc.identifier.pages4730
kaust.personAbdelrahman, Sherin
kaust.personAlghrably, Mawadda
kaust.personHauser, Charlotte
kaust.personJaremko, Mariusz
dc.date.accepted2021-07-29
refterms.dateFOA2021-08-08T08:16:46Z


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This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
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