CRISPR-Based Crop Improvements: A Way Forward to Achieve Zero Hunger
Mawia, Amos Musyoki
Rao, Gundra Sivakrishna
Mahfouz, Magdy M.
Biological and Environmental Science and Engineering (BESE) Division
Center for Desert Agriculture
Laboratory for Genome Engineering
Laboratory for Genome Engineering and Synthetic Biology, Division of Biological Sciences, 4700 King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia
Online Publication Date2021-07-21
Print Publication Date2021-08-04
Embargo End Date2022-07-21
Permanent link to this recordhttp://hdl.handle.net/10754/670290
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AbstractZero hunger is one of the sustainable development goals set by the United Nations in 2015 to achieve global food security by 2030. The current harvest of crops is insufficient; feeding the world's population and meeting the goal of zero hunger by 2030 will require larger and more consistent crop production. Clustered regularly interspaced short palindromic repeats-associated protein (CRISPR-Cas) technology is widely used for the plant genome editing. In this review, we consider this technology as a potential tool for achieving zero hunger. We provide a comprehensive overview of CRISPR-Cas technology and its most important applications for food crops' improvement. We also conferred current and potential technological breakthroughs that will help in breeding future crops to end global hunger. The regulatory aspects of deploying this technology in commercial sectors, bioethics, and the production of transgene-free plants are also discussed. We hope that the CRISPR-Cas system will accelerate the breeding of improved crop cultivars compared with conventional breeding and pave the way toward the zero hunger goal.
CitationAhmad, S., Tang, L., Shahzad, R., Mawia, A. M., Rao, G. S., Jamil, S., … Tang, S. (2021). CRISPR-Based Crop Improvements: A Way Forward to Achieve Zero Hunger. Journal of Agricultural and Food Chemistry. doi:10.1021/acs.jafc.1c02653
SponsorsWe are grateful to Dr. Rana Muhammad Atif from Department of Plant Breeding and Genetics, University of Agriculture, Faisalabad (UAF), Pakistan, for providing an ideal environment in his laboratory at the Center for Advanced Studies in Agriculture and Food Security (CAS-AFS), UAF, during the writeup of this manuscript. We also thank Prof. Dr. Asif Ali Khan (Vice Chancellor) from the Institute of Plant Breeding and Biotechnology, MNS University of Agriculture, Multan, Pakistan, for putting all his generous efforts in manuscript proofreading at the final stages. We apologize to colleagues whose work is not cited in this review owing to space limitations.
This work was supported by the National Key Science and Technology Program of China (Grant Number 2016YFD0101104), the Zhejiang Provincial Science and Technology Major Project on Breeding of Agricultural Crops (Grant Number 2016C02050-2), China National Key Research and Development program (Grant Number 2020YFE0202300), and KAUST baseline funding to Magdy M. Mahfouz.
PublisherAmerican Chemical Society (ACS)
Except where otherwise noted, this item's license is described as This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/10.1021/acs.jafc.1c02653.
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