Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium(v) complex
Kamble, Ganesh Tatya
KAUST DepartmentChemical Science Program
KAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Embargo End Date2022-06-23
Permanent link to this recordhttp://hdl.handle.net/10754/670186
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AbstractThe catalytic enantioselective oxidative hetero-coupling of arenols using a chiral vanadium(V) complex has been developed. The coupling of hydroxycarbazole derivatives with various arenols provided axially chiral biarenols with high chemo-, regio-, and enantioselectivities. The reaction took place under mild conditions and exhibited satisfactory functional group tolerance. Aerobic oxidative hetero-coupling with β-ketoesters also proceeded with high chemo- and stereoselectivities under slightly modified reaction conditions.
CitationSako, M., Higashida, K., Kamble, G. T., Kaut, K., Kumar, A., Hirose, Y., … Sasai, H. (2021). Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium(v) complex. Organic Chemistry Frontiers. doi:10.1039/d1qo00783a
SponsorsThis work was supported by JSPS KAKENHI Grant Numbers 20K15281 for Early-Career Scientists, JP17H05373 and JP18KK0154 in Promotion of Joint International Research (Fostering Joint International Research(B)), JST CREST Grant Number JPMJCR20R1, Daiichi Sankyo Foundation of Life, Hoansha Foundation, Iwatani Naoji foundation, and the NOVARTIS Foundation (Japan) for the Promotion of Science. We acknowledge the technical staff of the Comprehensive Analysis Center of ISIR, and Artificial Intelligence Research Center of ISIR, Osaka University (Japan).
PublisherRoyal Society of Chemistry (RSC)
JournalORGANIC CHEMISTRY FRONTIERS
Except where otherwise noted, this item's license is described as Archived with thanks to ORGANIC CHEMISTRY FRONTIERS