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dc.contributor.authorJimenez-Aleman, Guillermo H.
dc.contributor.authorAlmeida-Trapp, Marilia
dc.contributor.authorFernandez-Barbero, Gemma
dc.contributor.authorGimenez-Ibanez, Selena
dc.contributor.authorReichelt, Michael
dc.contributor.authorVadassery, Jyothilakshmi
dc.contributor.authorMithoefer, Axel
dc.contributor.authorCaballero, Julio
dc.contributor.authorBoland, Wilhelm
dc.contributor.authorSolano, Roberto
dc.date.accessioned2021-07-12T06:28:28Z
dc.date.available2021-07-12T06:28:28Z
dc.date.issued2019
dc.date.submitted2019-04-23
dc.identifier.citationJimenez-Aleman, G. H., Almeida-Trapp, M., Fernández-Barbero, G., Gimenez-Ibanez, S., Reichelt, M., Vadassery, J., … Solano, R. (2019). Omega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1864(12), 158520. doi:10.1016/j.bbalip.2019.158520
dc.identifier.issn1879-2618
dc.identifier.issn1388-1981
dc.identifier.doi10.1016/j.bbalip.2019.158520
dc.identifier.urihttp://hdl.handle.net/10754/670128
dc.description.abstractJasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity and signals through the canonical JA-pathway. The results suggest that 12-OH-JA-Ile differentially activates a subset of JA-Ile co-receptors that may control and/or modulate particular jasmonate dependent responses. It is proposed that after a strong immune response mediated by JA-Ile, the ω-hydroxylated form modulates JA-Ile activated processes thereby improving plant resilience.
dc.description.sponsorshipFellowships granted by the DFG to G.H.J.A. (Grant JI 241/2-1) and by CAPES-Humboldt to M.A.T. (Grant 99999.007611/2015-03) are gratefully acknowledged. Work in R. Solano's lab was funded by the Spanish Ministry for Science and Innovation grant BIO2016-77216-R (MINECO/FEDER). The authors thank the Max Planck Society for funding. We thank Andrea Lehr for technical assistance and the MPI-CE greenhouse team for cultivation of plants. The authors thank Prof. T. Heitz for providing the b1b3c1 mutant.
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S138819811930160X
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, [1864, 12, (2019)] DOI: 10.1016/j.bbalip.2019.158520 . © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFatty acids
dc.subjectOxylipin
dc.subjectPhytohormone
dc.subjectJasmonate
dc.subjectomega-Hydroxylation
dc.titleOmega hydroxylated JA-Ile is an endogenous bioactive jasmonate that signals through the canonical jasmonate signaling pathway
dc.typeArticle
dc.contributor.departmentKAUST
dc.identifier.journalBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
dc.identifier.wosutWOS:000498292900010
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Plant Molecular Genetics, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas (CNB-CSIC), 28049 Madrid, Spain
dc.contributor.institutionDepartment of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, 07745 Jena, Germany
dc.contributor.institutionDepartment of Biochemistry, Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, 07745 Jena, Germany
dc.contributor.institutionResearch Group Plant Defense Physiology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Str. 8, 07745 Jena, Germany
dc.contributor.institutionCentro de Bioinformática y Simulación Molecular (CBSM), Facultad de Ingeniería, Universidad de Talca, 1 Poniente 1141, Talca, Chile
dc.identifier.volume1864
dc.identifier.issue12
dc.identifier.pages158520
kaust.personAlmeida-Trapp, Marilia
dc.date.accepted2019-08-26
dc.identifier.eid2-s2.0-85071839680


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