Show simple item record

dc.contributor.authorAlsaedi, Sammar
dc.contributor.authorBabgi, Bandar A.
dc.contributor.authorAbdellatif, Magda H.
dc.contributor.authorEmwas, Abdul-Hamid M.
dc.contributor.authorJaremko, Mariusz
dc.contributor.authorHumphrey, Mark G.
dc.contributor.authorHussien, Mostafa A.
dc.date.accessioned2021-07-11T05:52:00Z
dc.date.available2021-07-11T05:52:00Z
dc.date.issued2021-07-07
dc.date.submitted2021-03-04
dc.identifier.citationAlsaedi, S., Babgi, B. A., Abdellatif, M. H., Emwas, A.-H., Jaremko, M., Humphrey, M. G., & Hussien, M. A. (2021). Effect of Net Charge on DNA-Binding, Protein-Binding and Anticancer Properties of Copper(I) Phosphine-Diimine Complexes. Journal of Inorganic and Organometallic Polymers and Materials. doi:10.1007/s10904-021-02063-5
dc.identifier.issn1574-1443
dc.identifier.issn1574-1451
dc.identifier.doi10.1007/s10904-021-02063-5
dc.identifier.urihttp://hdl.handle.net/10754/670098
dc.description.abstractAbstractThe syntheses of [Cu(PPh3)2(L)]NO3 and [Cu(PPh3)2(L-SO3Na)]NO3 were achieved through the reaction of Cu(PPh3)2NO3 and equimolar amount of the ligands (L = 5,6-diphenyl-3-[2-pyridyl]-1,2,4-triazine; LSO3Na = 5,6-diphenyl-3-[2-pyridyl]-1,2,4-triazine-4,4′-disulfonic acid disodium salt). The complexes were characterized by NMR and IR spectroscopy and mass spectrometry. The compounds exhibit similar absorption and emission spectra, suggesting a similar electronic structure. Ct-DNA binding studies show the strong influence of the net charge as Cu-L (positively charged) is able to bind to ct-DNA while Cu-LSO3Na (negatively charged) is not. The net charge of the complexes affects the thermodynamic and kinetic binding parameters toward human serum albumin. HSA-binding of the complexes was further investigated by molecular docking, revealing different binding sites on the HSA protein as a function of the net charge. The different anticancer activities of the complexes towards ovcar-3 and hope-62 cancer cell lines are suggestive of a role for the overall charge of the complexes. Interaction with the DNA is not the major mechanism for this class of complexes. The overall net charge of the pharmacophore (anticancer agent) should be a key consideration in the design of anticancer metal complexes.
dc.description.sponsorshipThis project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, Saudi Arabia, under grant no. (KEP-44-130-40). The authors, therefore, acknowledge with thanks DSR technical and financial support.
dc.publisherSpringer Science and Business Media LLC
dc.relation.urlhttps://link.springer.com/10.1007/s10904-021-02063-5
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEffect of Net Charge on DNA-Binding, Protein-Binding and Anticancer Properties of Copper(I) Phosphine-Diimine Complexes
dc.typeArticle
dc.contributor.departmentNMR
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalJournal of Inorganic and Organometallic Polymers and Materials
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
dc.contributor.institutionChemistry Department, Deanship of Scientifc Research, College of Sciences, Taif University, P.O. Box 11099, Al-Haweiah Taif 21944, Saudi Arabia.
dc.contributor.institutionResearch School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
dc.contributor.institutionDepartment of Chemistry, Faculty of Science, Port Said University, Port Said 42521, Egypt.
kaust.personEmwas, Abdul-Hamid M.
kaust.personJaremko, Mariusz
dc.date.accepted2021-06-25
refterms.dateFOA2021-07-11T05:53:01Z
dc.date.published-online2021-07-07
dc.date.published-print2021-10


Files in this item

Thumbnail
Name:
Alsaedi2021_Article_EffectOfNetChargeOnDNA-Binding (1).pdf
Size:
1.691Mb
Format:
PDF
Description:
Publisher's version

This item appears in the following Collection(s)

Show simple item record

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Except where otherwise noted, this item's license is described as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.