Stimuli-Responsive Lysozyme Nanocapsule Engineered Microfiltration Membranes with a Dual-Function of Anti-Adhesion and Antibacteria for Biofouling Mitigation
Vrouwenvelder, Johannes S.
KAUST DepartmentBiological and Environmental Science and Engineering (BESE) Division
Environmental Science and Engineering Program
Water Desalination and Reuse Research Center (WDRC)
Online Publication Date2021-07-05
Print Publication Date2021-07-14
Embargo End Date2022-07-05
Permanent link to this recordhttp://hdl.handle.net/10754/670037
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AbstractBiofouling remains as a persistent problem impeding the applications of membranes for water and wastewater treatment. Green anti-biofouling of membranes made of natural and environmentally friendly materials and methods is a promising strategy to tackle this problem. Herein, we have developed a functionalized PVDF membrane with stimuli-responsive lysozyme nanocapsules (NCP). These nanocapsules can responsively release lysozyme according to environmental stimuli (pH and redox) induced by bacteria. Results showed that (i) the surface of the functionalized membrane with NCP had enhanced hydrophilicity, reduced roughness, and negative charge, (ii) a remarkable reduction of adsorption of proteins, polysaccharides, and bacteria was achieved by the functionalized membrane, and (iii) the colony forming unit (CFU) of bacteria on a membrane surface was reduced more than 80% within 24 h of contact. In addition, the NCP membrane showed excellent anti-biofouling activity regarding the bacterial viability being 12.5 and 8.3% on the membrane after filtration with 108 CFU mL–1Escherichia coli and Staphylococcus aureus solution as feed, respectively. The coating layer and assembled nanocapsules endowed the membrane with improved lysozyme stability, anti-adhesion performance, and antibacterial activity. Stimuli-responsive lysozyme nanocapsule engineered microfiltration membranes show great potential for anti-biofouling in future practical application.
CitationLi, S., Zhao, S., Pei, J., Wang, H., Meng, H., Vrouwenvelder, J. S., & Li, Z. (2021). Stimuli-Responsive Lysozyme Nanocapsule Engineered Microfiltration Membranes with a Dual-Function of Anti-Adhesion and Antibacteria for Biofouling Mitigation. ACS Applied Materials & Interfaces. doi:10.1021/acsami.1c07445
SponsorsThe authors gratefully acknowledge the funding support by The National Key R&D Plan for International Cooperation in Science and Technology Innovation (project no. 2017YFE0181100) and the National Nature Science Foundation of China (project no. 21901212).
PublisherAmerican Chemical Society (ACS)