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dc.contributor.authorZhang, Junrui
dc.contributor.authorVancea, Alexandra
dc.contributor.authorShahul Hameed, Umar F.
dc.contributor.authorArold, Stefan T.
dc.date.accessioned2021-06-08T05:59:46Z
dc.date.available2021-06-08T05:59:46Z
dc.date.issued2021-05-14
dc.date.submitted2021-03-16
dc.identifier.citationZhang, J., Vancea, A. I., Shahul Hameed, U. F., & Arold, S. T. (2021). Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins. Computational and Structural Biotechnology Journal, 19, 3125–3132. doi:10.1016/j.csbj.2021.05.025
dc.identifier.issn2001-0370
dc.identifier.doi10.1016/j.csbj.2021.05.025
dc.identifier.urihttp://hdl.handle.net/10754/669443
dc.description.abstractIn plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.
dc.description.sponsorshipThis research was supported by the King Abdullah University of Science and Technology (KAUST) through the baseline fund and the Award No. URF/1/4039-01 from the Office of Sponsored Research (OSR). We thank I. Blilou for comments on the manuscript.
dc.publisherElsevier BV
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2001037021002063
dc.rightsThis is an open access article under the CC BY license.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleVersatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins
dc.typeArticle
dc.contributor.departmentBioscience
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentKing Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Biological and Environmental Science and Engineering (BESE), Thuwal 23955-6900, Saudi Arabia
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.identifier.journalComputational and Structural Biotechnology Journal
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionCentre de Biochimie Structurale, CNRS, INSERM, Université de Montpellier, 34090 Montpellier, France
dc.identifier.volume19
dc.identifier.pages3125-3132
kaust.personZhang, Junrui
kaust.personVancea, Alexandra-Ioana
kaust.personShahul Hameed, Umar F.
kaust.personArold, Stefan T.
kaust.grant.numberURF/1/4039-01
dc.date.accepted2021-05-13
dc.identifier.eid2-s2.0-85107058267
refterms.dateFOA2021-06-08T06:01:24Z
kaust.acknowledged.supportUnitOffice of Sponsored Research (OSR)


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