Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins
KAUST DepartmentBiological and Environmental Science and Engineering (BESE) Division
Computational Bioscience Research Center (CBRC)
Environmental Science and Engineering Program
King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Biological and Environmental Science and Engineering (BESE), Thuwal 23955-6900, Saudi Arabia
Structural Biology and Engineering
KAUST Grant NumberURF/1/4039-01
Online Publication Date2021-05-14
Print Publication Date2021
Permanent link to this recordhttp://hdl.handle.net/10754/669443
MetadataShow full item record
AbstractIn plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.
CitationZhang, J., Vancea, A. I., Shahul Hameed, U. F., & Arold, S. T. (2021). Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins. Computational and Structural Biotechnology Journal, 19, 3125–3132. doi:10.1016/j.csbj.2021.05.025
SponsorsThis research was supported by the King Abdullah University of Science and Technology (KAUST) through the baseline fund and the Award No. URF/1/4039-01 from the Office of Sponsored Research (OSR). We thank I. Blilou for comments on the manuscript.
Except where otherwise noted, this item's license is described as This is an open access article under the CC BY license.