Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins
Biological and Environmental Sciences and Engineering (BESE) Division
King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Biological and Environmental Science and Engineering (BESE), Thuwal 23955-6900, Saudi Arabia
Computational Bioscience Research Center (CBRC)
KAUST Grant NumberURF/1/4039-01
Permanent link to this recordhttp://hdl.handle.net/10754/669442
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AbstractIn plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes. The resulting changes in protein or RNA content are an important means for plants to control protein homeostasis and thereby adapt to shifting environmental conditions. The activity and targeting of CDC48 are controlled by adaptor proteins, of which the plant ubiquitin regulatory X (UBX) domain-containing (PUX) proteins constitute the largest family. Emerging knowledge on the structure and function of PUX proteins highlights that these proteins are versatile factors for plant homeostasis and adaptation that might inspire biotechnological applications.
CitationZhang, J., Vancea, A. I., Shahul Hameed, U. F., & Arold, S. T. (2021). Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins. Computational and Structural Biotechnology Journal, 19, 3125–3132. doi:10.1016/j.csbj.2021.05.025
SponsorsThis research was supported by the King Abdullah University of Science and Technology (KAUST) through the baseline fund and the Award No. URF/1/4039-01 from the Office of Sponsored Research (OSR). We thank I. Blilou for comments on the manuscript.
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